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　　Xinhua News Agency, Beijing, January 13th-Maria Van Kierke Hoff, technical director of the World Health Organization’s health emergency project, pointed out on the 12th that with the increase of people’s social activities and the prevalence of other respiratory pathogens such as influenza virus in spring, it is expected that COVID-19 and other respiratory diseases will break out at the same time in the future. She urged countries to prepare for this and ensure the integrated operation of respiratory disease surveillance systems. Recently, many countries around the world have also reported cases of "double infection" of Covid-19 and influenza virus.

　　Will the symptoms of being infected with both viruses be more serious? How to prevent it?

　　Covid-19 and influenza virus belong to respiratory viruses, and they may have similar symptoms after infection, such as cough, runny nose, sore throat, fever, headache, etc., and both of them are spread by droplets and aerosols when talking, coughing and sneezing.

　　Experts said that winter is the high incidence of influenza, and the Omicron strain of COVID-19 mutant virus is rampant, and the possibility of contracting influenza and COVID-19 is also increasing. Due to the limited data, it is not clear whether double infection will lead to more serious consequences, but simultaneous infection with two viruses may bring a greater blow to the human immune system.

　　WHO emphasizes that the most effective way to prevent the serious consequences of double infection of COVID-19 and influenza is to vaccinate COVID-19 vaccine and influenza vaccine respectively, and at the same time, continue to take preventive measures, such as keeping social distance, wearing masks, washing hands frequently and strengthening indoor ventilation.

　　It should be noted that experts do not recommend to vaccinate COVID-19 vaccine and influenza vaccine at the same time. According to China’s Technical Guidelines for Vaccination in Covid-19 (First Edition), it is suggested in principle that the interval between influenza vaccination and Covid-19 vaccination should be more than 14 days.

　　Experts also advise people to pay attention to cold and warmth, take proper physical exercise, strengthen nutrition and build up their physique. If you have symptoms such as respiratory discomfort and fever, you should seek medical attention in time, pay attention to home isolation, go to work and class without illness, and wear masks when contacting family members or going to the hospital to avoid cross-infection.

Special feature of 1905 film network The drama of the Eight Immortals crossing the sea in the Spring Festival in 2019 has not yet been staged, and the smoke of the three countries’ hegemony in 2020 has begun to diffuse.

As the most important schedule in the current year, the warm-up of the Spring Festival stalls has changed from the past few months to nearly one year in advance.

As early as March 26 last year, it was announced that it would be the first day of this year.

In July, it became the second film scheduled for the first day of the New Year.

In August, Han Han also announced his entry into the Spring Festival.

It was a little late, and it was only at the end of October that I decided to enter the Spring Festival.

However, in the propaganda front of the Spring Festival in 2020, the operation in 2018 is really nothing. Because, before the Spring Festival in 2019, there are already movies on almost the same day, announcing that they will be released in the Spring Festival in 2020.

First, Xú Zhēng sent a Weibo on January 23rd, hinting that he was lost again. The next day, the story happened in Lost in Russia, Russia, where it was announced that it would be the first day of 2020.

In the same year, it was also announced the day of the file. At the same time, it is widely rumored on the Internet that Lin Chaoxian’s new work will also focus on this schedule.

When is the New Year’s Day in 2020?January 25th! It’s just a year later.

11 days earlier than this year’s Spring Festival. Small electric gentleman smells a little bad.

There may be no film for this year’s New Year’s Eve.

This was once the most important schedule of China movies, but now it has gradually become a chicken rib. Why don’t all the films now want to go to the New Year’s Eve file?

Maybe my friends now are forgetting the glory of the previous Lunar New Year file. In 1995, Jackie Chan became the first Hong Kong film to be introduced to the mainland in the name of a New Year film, which sold 80 million yuan.

Since 1997, with the speed of one film a year, comedies have become the standard and box office guarantee for New Year’s Eve files. Every December, there will be a wave of movie-watching frenzy.

It is not only a comedy, but also a new year’s eve file has become the exclusive schedule for big directors and big productions. Zhang Yimou, Chen Kaige, Tsui Hark, Jiang Wen and others are frequent visitors to the New Year’s Eve stalls. Box office champions are also almost New Year’s Eve players.

2011 annual box office champion and runner-up;

Champion and runner-up in 2012;

Xiao Dianjun will not list them one by one.

Although traditionally, the Lunar New Year holiday is about the last two weeks of December, if we look at the box office in December, of the 13.1 billion box office in 2011, the box office in December was 1.309 billion, second only to the summer holiday in July and August.

Since 2012, the Lunar New Year file has never fallen below the box office figure of 2 billion. In 2015, the box office in December reached 4.194 billion, ranking behind July and October.

Although the Lunar New Year file can still continue to export more than 4 billion box office for the whole year, movies with big production and big IP have already set their sights on the Spring Festival file.

A few years ago, you can still see such a large-scale film in the Lunar New Year file, but now, the Lunar New Year file seems to have entered a situation where there are no films to watch.

"The box office of the Spring Festival for several consecutive years is too amazing, and ambitious films will naturally be more willing to go to the Spring Festival." Uncle Fei, who works in a film company, said. In his view, the New Year’s Eve is a bit awkward, there is no holiday, and it is stuck between the National Day and the Spring Festival. "Then why don’t I go to a bigger market space?"

Indeed, after breaking 1 billion in 2013 and raising the box office in February to 2 billion, the Spring Festival has become a more and more important schedule for the film.

In 2014, the top three competed for hegemony, and the box office in February exceeded 3 billion.

In 2016, the box office of a movie reached 3.1 billion, which broke the box office record of Chinese movies at this time and made the film company realize how big the capacity of the Spring Festival file is.

The Spring Festival, which spans January and February, has crossed the Lunar New Year file in just five years, becoming a schedule giant alongside the summer file.

The traditional four schedules of Spring Festival, Summer Holiday, National Day and New Year’s Eve are also slowly being adjusted to the two strong schedules of Spring Festival and Summer Holiday and the direction of having key films every month.

In particular, comedies and family-happy movies have moved from the New Year file to the Spring Festival file as a whole.

"Although there is a struggle with the opponent in the schedule, for example, I am the first choice film for the audience in the Lunar New Year file, so why should I go to the Spring Festival file to make a fourth choice film?However, if there is a strong outer film, it means that the space of domestic films will be crushed. The most typical example this year is."When talking about why the 2018 Lunar New Year file is not as powerful as before, a film planner said this.

He said that it is inevitable for a large number of movies to go to the big schedule: "The choice of schedule is mainly the living space and competitors, and there is also a volume problem, that is, quality and volume are not directly proportional. These two concepts are not directly related. In fact, you said that the quality of some films released in the Spring Festival file must be better than that of the box office champion" The Ring of Calls "? I don’t think so, but the volume is much larger than that of "The Call is Crazy". "

Uncle Fei, who works for a film company, also said,The amazing box office of the Spring Festival file has long been turned into a customized film for the Spring Festival file by a film company, and it was indicated that it was going to the Spring Festival before shooting.

Zhou Yuli, a writer, believes that the decline in the weight and status of the New Year’s Eve file is the inevitable result of the China film market becoming bigger and stronger. In "New Year’s File: Why Are Domestic Movies Silent?" In the article, he mentioned the emergence and prosperity of the New Year’s Eve file.In fact, it is the result of the small film market and low film production in the past 20 years. It is impossible to fill the vacancy of each schedule, which makes the effect of the Lunar New Year file expand and makes the low-frequency movie-watching group enter the theater.

However, since 2003, the box office of Chinese movies has maintained a growth rate of 30%.The annual box office in 2018 has exceeded 60 billion, 60 times that of 2003.

Behind the prosperity of the box office is the increase in the number of cinemas, the number of screens and the output of movies. The development of this speed no longer depends on the support of a single schedule, and the Lunar New Year file naturally has no "strategic essence" in the past.

Watching movies has now become a "new folk custom" during the Spring Festival. The low-frequency audience who used to walk into the cinema in the Lunar New Year file has now become the audience in the Spring Festival file.

"The habit of watching movies during the Spring Festival is to go to the cinema together. Everyone has gone home. The box office in the third-and fourth-tier cities is actually much more than the first-and second-tier in the space of the Spring Festival. They are all watching with their parents or with the children at home. " The film planner interviewed above said this.

This also makes movies with large volume and large resources flow to the Spring Festival file one after another. "Movies with high volume and quality. That must be squeezing into a strong position. If word of mouth is here, the attendance rate will not drop. The cinema will have confidence in arranging films.If the quality of the films entering the Spring Festival is directly proportional to the volume, it is definitely a plus item."He added.

It can be seen that the promotion of the schedule to the box office is on the one hand, but the film quality is the addition of the schedule box office. A good movie brings a good schedule, just as the New Year’s Eve file opened by "Party A and Party B" and "Journey to the West and Demons" let the film companies see the box office potential of the Spring Festival file.

Although the Lunar New Year file is influenced by the siphon effect of the Spring Festival file as the current super-strong schedule because it is near the Spring Festival, it is now an era when good movies can shine in the unpopular schedule. Let’s hope that the film will rediscover the value of the New Year file.

Dolphin supply chain belongs to Shenzhen Youkeshu Technology Co., Ltd., founder and CEO Xiao Siqing.

About Dolphin Supply Chain

Following the national "One Belt, One Road" strategy, Dolphin Supply Chain is the first cross-border Haitao supply chain brand to cooperate with CEIBS. It is committed to providing global high-quality goods to thousands of families in China and becoming a deep distributor of foreign high-quality brands in China. Supported by genuine products and extreme speed, Dolphin focuses on the field of importing Haitao, and deeply arranges the whole process of importing cross-border e-commerce to help upgrade domestic consumption. Since the establishment of Dolphin Supply Chain, its performance has maintained rapid growth, with revenue exceeding 360 million in 2015, 970 million in 2016, an increase of 168.90%, and the target revenue in 2017 is 2 billion.

Main products

Including maternal and child products, food health care, beauty care and daily necessities, it is aimed at more than 10,000 B-end wholesale sales customers and more than 45 million C-end users such as JD.COM, Vipshop, Honey Bud, Xiaohongshu, Suning.cn and Beibei. At present, it has become the largest cross-border supply chain brand of B-end cross-border imports in China.

superiority

1. Global depth layout

Dolphin supply chain has set up overseas branches or teams in Germany, the Netherlands, Britain, Australia, the United States, Japan, South Korea, Hong Kong and other countries and regions, and set up overseas warehousing and logistics bases in these countries and regions of origin. Dolphin supply chain has the integration advantages of the fastest supply chain in six regions around the world, providing professional one-stop service for cross-border e-commerce.

2. Six major purchasing centers

Dolphin supply chain has built six major procurement centers in the world, looking for strong local suppliers to ensure stable supply and quality of goods.

3. Strong brand channels

Dolphin supply chain actively develops brand authorization and cooperates with brand manufacturers in depth. It has obtained the authorization, agency and even exclusive agency of dozens of well-known maternal and infant and health care products brands in the world, and has the professional operation ability of overseas brands in China.

4. Extreme logistics service

Dolphin supply chain has creatively created a closed-loop model of "overseas warehouse+Hong Kong warehouse+domestic bonded warehouse", forming a warehousing and logistics network with 24-hour response all over the world. In addition, the Dolphin Supply Chain continuously optimizes the logistics delivery channels, comprehensively covers the four transportation modes of "sea, land and air rail", and is equipped with a professional customs team to minimize the processing time of each customs clearance link.

5, the ultimate direct mail experience

At present, Dolphin Supply Chain vigorously develops overseas direct mail business, and relies on mature cross-border logistics experience and accurate supply chain control ability to provide domestic consumers with massive global quality goods and bring the ultimate direct mail experience.

6, award-winning

Dolphin supply chain has won many honors such as airport leader, the best cross-border e-commerce supply chain service provider, the outstanding achievement award of cross-border e-commerce of Hong Kong cross-border electronic commerce Industry Association and the top 10 cross-border e-commerce supply chain enterprises in Guangdong Province with its strong competitiveness and contribution to cross-border Haitao supply chain.

finance

In June, 2015, the Dolphin Supply Chain received RMB 160 million Series A financing invested by Tomson Bianjian.

In November, 2015, Dolphin Supply Chain received a series B financing of over RMB 100 million jointly invested by Guangfa Shunde and Haitong Innovation Capital. In 2015, after the B round of financing, it launched a cross-border Haitao B-end, and became a supplier of maternal and child health care products at the C-end of many well-known cross-border e-commerce companies such as JD.COM Global Buy, Netease Koala, Weipin International, Beibei.com and Xiaohongshu. amz123

In December 2018, Dolphin Supply Chain signed strategic cooperation agreements with a number of Chinese and foreign banks such as Citigroup and HSBC, with a total amount of credit financing reaching tens of millions of dollars. According to the content of the agreement, the two sides will reach cooperation in financing business, cash management, international financial business and other business fields to further stimulate the market vitality of the dolphin supply chain.

development history

-In 2015, in line with the rise of Haitao fever, the company began to invest in cross-border Haitao and create the brand of "Dolphin Supply Chain".

-In October 2015, the Dolphin Supply Chain of Youshu was launched in the European Central Warehouse.

-In 2015, the revenue exceeded 360 million.

-In April 2016, the brand-new Europe No.2 central warehouse was launched.

-The revenue in 2016 was 970 million, an increase of 168.90%.

As a "star" in the fruit industry, during the Spring Festival, the consumption of cherries continues to increase, and the price of cherries attracts attention. It looks like a ruby, refreshing and delicious, with moderate sweetness and sourness.

During the cherry consumption season, a large number of cherries appeared in fruit shops and e-commerce platforms. 2J, 3J, 4J…… … They come in different sizes and colors, and have various packages, but they have one thing in common, that is, they are basically produced in Chile.

【1】

At present, Chilean cherries can be said to be the "most valuable" fruit in fruit shops. Because its 40-day sales period coincides with the Spring Festival in China, it has become a high-end gift for people to visit relatives and friends during the festival.

According to Red Star News, in mid-January, the price of a box of 5 kilograms of cherries was 400 yuan, and "not a penny less". But at the end of January, more Chilean cherries arrived in China by sea, and the price of 5 kilograms of cherries has been reduced to 320 yuan. With the price reduction, "Cherry Freedom" has also been searched.

Xiaobai, who lives in Santiago, Chile, told reporters that cherries are the cheapest fruit in the local area, and ordinary people can afford it. Although Chile is a big fruit exporter, there are not many varieties of fruits, with one kilogram of bananas in 5 yuan and one kilogram of cherries in 5.7 yuan, which is close to the price of bananas. "At the end of November, cherries have just been listed in Chile, and the price is not cheap, 10 yuan/kg."

After Jia Xi came to Chile, he found that the freedom of cherries could be realized here, but the price of restaurants was quite high. "The main reason in Chile is that labor is too expensive. The price of buying vegetables and selling meat in supermarkets is not outrageous, and it is very expensive to go out for a meal and get a haircut." He told reporters that eating fried rice and a dish in a restaurant costs 7,000 Chilean pesos (about RMB 52 yuan), and the price of a barbecue for three people is 100,000 Chilean pesos.

In China market, the main variety of Chilean cherries is Rubins. Cherries are generally graded by 2J, 3J, etc. The bigger the number, the bigger the size and the more expensive the price. According to reports, fruit merchants in Kunming, Yunnan, said that it is difficult for consumers to distinguish different grades of cherries, and some wholesalers will re-brand them as inferior products. Some cherries sold very cheaply have many small rotten fruits, so consumers should buy them carefully.

【2】

Every November to the next two years is the season for picking Chilean cherries. These "rubies" were picked, sorted and packaged, crossed the equator and transported to China on the other side of the ocean.

China imports cherries from Chile, New Zealand and Australia. Among them, the export share of Chilean cherries, China accounted for as much as 90% in the world, far exceeding other countries.

The huge growth potential of China market has given confidence to Chilean cherries industry, and many farmers have expanded their planting area. In 2023, the planting area of Chilean cherries reached a record 67,570 hectares. Because the profit of cherries is higher than that of apples, many fruit farmers cut down apple trees and replant cherries. Therefore, the planting area of Chilean cherries has increased nearly 18 times in the past 22 years.

According to the data of Frutas de Chile, the export volume of Chilean cherries to China has increased by about 29% annually in the past seven years. In the 2023/24 season, as of the fourth week of this year, a total of 399,000 tons of cherries departed from Chile and went to all parts of the world, a decrease of 3.8% compared with 415,000 tons in the same period of the previous season. However, China’s position in Chile’s cherry export market is stronger, with 92% of cherries sent to China.

When Chilean cherries entered the China market in 2010, the import volume was only 500,000 US dollars. In 2019, the import volume of China exceeded 1 billion US dollars, a 200-fold increase in ten years. From the import data, in 2018, Chilean cherries surpassed American cherries. In that year, the total import volume of cherries in China reached 186,000 tons, of which 163,000 tons came from Chile, accounting for nearly 90%.

According to the data of China Customs, on December 28th, 2023, the first COSCO Shipping "Cherry Express" this winter loaded 216 refrigerated containers, totaling nearly 4,536 tons of Chilean cherries, and arrived at Shanghai Yangshan Port.

According to People’s Daily, on January 27th, a cargo ship carrying 19,000 tons of Chilean cherries docked at Guangzhou Nansha Port, which became the port with the largest import volume of cherries in China during the 2022 -2023 season. In the mainland market of China, one of every two Chilean cherries is imported from Nansha Port. Throughout the 2023-2024 season, about 100,000 tons of cherries were imported from this.

After a large number of fruits come from across the ocean, the port staff will inspect them to prevent the risk of plant epidemic and food safety hazards. Three weeks before the Spring Festival is the peak season for the sales of imported cherries. With the stability of the quality in Chile, the arrival of cherries has increased, and the price has also dropped.

According to the report of national business daily, when cherries first came into the market, they were expensive because of the small quantity and high air transportation cost. With the increase of output, a large number of cherries arrived in China by sea, the logistics and insurance costs decreased, and the price of cherries continued to decline. Every February, imported cherries enter the stage of processing the tail goods, and fruit merchants will sell them at a reduced price as soon as possible to avoid not selling them. From December of each year to February of the following year, the price reduction of cherries presents a periodic law.

The Chilean Fruit Exporters’ Association said, "One of our medium-term strategies in China is to increase the frequency and quantity of cherries purchased by everyone on various occasions every season. Now the promotion of Chilean cherries pays more attention to real life scenes such as three meals a day, casual snacks and holiday gifts, hoping to establish more emotional links with consumers. "

Under this strategy, "high-end fruit" cherries are entering the lives of consumers in China.

Kun Shang Wu [2023] No.2

County (city) district, development (holiday) district commercial departments, relevant offices (units) of the bureau, relevant enterprises:

According to the spirit of "Notice of Yunnan Provincial Department of Commerce on Doing a Good Job in the Pilot Work of Chain Operation Development", in order to do a good job in the pilot project of chain operation development in our city, our bureau has studied and formulated the "Kunming Chain Operation Development Pilot Implementation Plan", which is hereby printed and distributed to you, please earnestly implement it. Work and experience summary shall be submitted to the Municipal Bureau of Commerce in a timely manner.

Kunming Bureau of Commerce

January 11, 2023

Kunming chain operation development pilot implementation plan

In order to better build a large domestic cycle, stimulate economic vitality, and promote the effective improvement of quality and reasonable growth of quantity, we insist on focusing on the real economy in developing the economy. According to the spirit of Notice of Yunnan Provincial Department of Commerce on Doing a Good Job in the Pilot Work of Chain Operation Development, give full play to the role of chain operation in expanding the effective supply of goods and services, expand domestic demand, promote consumption, ensure production and serve people’s livelihood through the development of chain operation, continuously improve residents’ consumption convenience and quality of life, and create a "new engine" for consumption upgrading, so as to ensure the development and growth of chain operation in our city and smoothly promote the pilot work, and formulate this plan.

I. Guiding ideology

Guided by Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, we will fully implement the spirit of the 20th and 19th plenary sessions of the Party, persist in promoting high-quality development, and meet the people’s longing for a better life and demand for convenient consumption in accordance with the principle of "market-oriented, basic guarantee, rational allocation, harmonious business and residential development". With the development idea of "government guidance, market operation, focusing on people’s livelihood, optimizing layout, improving functions and simplifying licensing", we will promote the "six unifications" of chain operation (unified image identification, unified store management and control, unified facility configuration, unified service standards, unified commodity procurement, unified logistics and distribution), focus on retail, catering and other industries, and combine various formats serving people’s livelihood in a chain operation way to cultivate a number of large-scale and large-scale enterprises.

Second, the basic principles

(1) Government guidance and market dominance. Give full play to the guiding role of government planning, improve the policy system and increase investment in public resources. Give full play to the decisive role of the market in resource allocation, encourage all kinds of social subjects to participate in chain operation, and enhance the service function and sustainable development ability of chain operation.

(two) people-oriented, basic protection. The pilot construction of chain operation development must adapt to the construction and development of livable environment system, meet the requirements of livability, convenience and benefit, convenience and speed, safe consumption and no nuisance to the people, gradually realize the daily consumption of residents in the community and continuously meet the growing needs of the people for a better life.

(3) Scientific planning and rational allocation. The pilot construction of chain operation development should be coordinated with the land space planning and commercial network planning, with overall allocation, moderate advance, synchronous planning, synchronous design and synchronous construction with residential and other public facilities to avoid waste of resources. Commercial facilities should be rationally allocated in the renovation of old residential areas.

(4) Intensive construction and harmonious business and residence. Combined with the implementation of urban renewal, revitalize the existing facilities resources, focus on the construction of new facilities, improve the efficiency of facilities, and advocate "one store with multiple functions and one store with multiple functions" on the premise of ensuring safety to avoid large-scale demolition and construction. Create a harmonious consumption environment for business and residence, coordinate the business environment with the living environment, and match the development of business format with the needs of residents.

(5) Innovation-driven and diversified development. In addition to conforming to the norms, the pilot construction of chain operation development should also implement the current relevant national, provincial and municipal norms and industry standards. Encourage chain operation to develop into standardization, specialization, intelligence and specialization. Adhere to the typical guide, give play to the role of demonstration, and guide the standardized and orderly progress of the pilot construction of chain operation development.

Third, the main objectives

Adhere to high-quality development, around the construction of a modern economic system, in accordance with the commercial development layout plan of Kunming (2021-2030), support the extension of chain operation to multi-industries, multi-formats and rural areas, promote the innovation of community commercial formats in the form of chain operation, and expand convenience and value-added services. Strive to complete the mid-term goal of the pilot by the end of 2023: more than 3 chain stores will be added in the city, more than 50 brand chain convenience stores will be added, more than 100 chain stores will be added, and two or three chain stores with more than 200 stores will be cultivated; The final goal of the pilot project will be completed by the end of 2024: the number of chain stores will increase by 200 on the basis of 2023, and the coverage rate of chain stores will increase by 10 percentage points. Coordinate the chain operation and the pilot construction of the "15-minute convenient life circle", support chain convenience stores to enter the community, and realize the full coverage of 15 pilot communities of the "15-minute convenient life circle".

Fourth, the key work

　(1) Guide the large-scale development of chain enterprises. Cultivate and develop a number of large-scale chain enterprise groups with strong competitiveness based on local and cross-regional development. Promote Kunming time-honored brands and brand enterprises to highlight their main business, and expand their brand advantages by developing chain operations. Encourage chain enterprises with the same format to reorganize through mergers and acquisitions, equity participation, brand output and other forms, accelerate resource integration, and achieve low-cost expansion and cross-regional development. Encourage and support qualified chain enterprises to go public, and enhance their financing ability and development potential.

(two) improve the chain convenience service outlets. Incorporate convenience commercial facilities such as chain stores into the urban public service infrastructure system, clarify the technical requirements for planning, and implement the requirement that the area of newly-built community commercial and comprehensive service facilities accounts for no less than 10% of the total construction area of the community. Cultivate a number of chain brands with high market recognition, strong brand value growth and convenient and high-quality supporting services. Combine the development of chain operation with the construction of community commerce and rural circulation network to support a number of chain enterprises in the field of people’s livelihood. Encourage brand chain enterprises to enter the community, support chain commercial service enterprises related to people’s livelihood to set up outlets in the community and rural areas, give full play to the advantages of brand chain operation, provide standardized, convenient and high-quality services, improve the standardization level of people’s livelihood consumption supply side, and enable residents to consume conveniently and safely.

(3) Expand the level of chain operation industry. Promote the chain operation to multi-field and deep-level expansion. Encourage chain operation to extend from traditional commercial service fields such as commercial retail and catering to more other service fields, accelerate the development of chain operation in domestic service, health care for the aged, new bookstores, fresh supermarkets, child care, entertainment and fitness, information consultation and other service industries, and improve the industry coverage of chain operation. Encourage chain enterprises to develop direct chain stores with capital as the link, learn from the management mode and technical means of foreign franchising, and use franchise development, which is a connection mode of goods, trade names, brands, skills, distribution and management, to promote the standardized development of franchising.

(4) Promoting the innovation of chain business model. Encourage chain enterprises to develop new models and technologies and give play to their leading role in new consumption. Support chain enterprises to establish trade alliances or horizontal alliances cooperation relations, and increase the proportion of self-operation through centralized procurement, cooperative procurement, buyout operation and development of their own brands; Encourage chain enterprises to give full play to the advantages of logistics, service and experience of offline stores, and integrate with online business flow, capital flow and information flow to realize complementary advantages and integrated development of online and offline; Support chain enterprises to use e-commerce platform to innovate service mode, and provide intensive and convenient services such as online booking, online booking, door-to-door service and community distribution.

(5) Improve the information technology and logistics support system. Promote chain enterprises to use information technology for supply chain integration, strengthen upstream and downstream cooperation in the industrial chain, and meet personalized and diversified consumer demand. Improve the socialization, standardization, informationization and specialization of logistics distribution, support chain enterprises to carry out the construction and renovation of standardized distribution centers and store facilities and equipment, encourage the application of technologies such as the Internet of Things and big data in the logistics distribution system, support the construction of a unified distribution information service platform, and improve the proportion of unified procurement and centralized distribution of goods by chain enterprises; Encourage chain enterprises to cooperate with third-party logistics, support the construction of urban logistics distribution terminal network, encourage the promotion of common distribution mode, strengthen the construction of cold chain logistics system, and improve the efficiency and level of distribution.

(6) Optimize the access approval mechanism. Further optimize the approval process, shorten the approval time for chain enterprises, and provide convenient registration services for chain enterprises. For chain enterprises whose business scope does not involve licensed operation, the trial registration of "one photo and multiple addresses" requires only one business license in the first district. If other direct stores are set up in the district, the registration of one photo and multiple addresses will be handled, and the registration of branches will no longer be handled. Explore and simplify the examination and approval procedures for tobacco business. Further refine the food business license standards, implement the "notification commitment system" for food business of brand chain convenience stores, carry out simple food heating convenience services for chain convenience stores, simplify the licensing procedures and requirements, and shorten the time limit for food business license review and certification.

(seven) to strengthen the construction of chain professionals. Improve the multi-level training system for business circulation talents in colleges and universities, vocational colleges, social vocational education and enterprise training, and promote the growth of compound high-end business talents, information services, logistics and distribution and other chain management talents. Support industry associations to carry out industry talent training, encourage chain enterprises to improve their own talent incentive mechanism, and maintain the relative stability of the talent team.

V. Support measures

(1) Cultivate brand chain leading enterprises. Introduce and cultivate a number of large and medium-sized brand chain enterprises with strong competitiveness based on local and cross-regional development, promote the development of chain enterprises, encourage and promote qualified chain enterprises to "go global" around the construction of Kunming as a regional international center city, and promote the cross-regional development of chain enterprises. For well-known international and domestic chain enterprises to set up their headquarters in our city, they can enjoy the relevant policies of the city’s headquarters economy in line with the conditions. For chain-operated enterprises that set up headquarters or branches in our city according to the requirements of the "six unifications" standard and the number of newly-added stores exceeds 20, a one-time subsidy of 10,000 yuan will be given for each newly-opened direct-operated store with an operating period of not less than one year, and a one-time subsidy of 5,000 yuan will be given for each newly-opened franchise store with an operating period of not less than one year. The maximum subsidy enjoyed by single-family chain enterprises is not more than 300,000 yuan. For newly opened (acquired) chain stores outside the city, a one-time bonus will be given according to the standard that each store does not exceed 15,000 yuan. For newly opened franchise chain stores, each store will be given a bonus of 5,000 yuan, and single-family chain enterprises will enjoy the maximum subsidy of 400,000 yuan.

(2) Digital empowerment chain management development. Encourage chain enterprises to make full use of modern information technology, promote chain stores in online to offline, carry out omni-channel operation, and provide residents with online orders, offline experience, home delivery, community group purchase and other services. Encourage chain enterprises to improve the coverage of digital management, explore the development of new convenient retail terminals such as smart retail cabinets, support chain enterprises to improve the level of intelligent management, and support enterprises to establish a smart supply chain driven by consumer big data, such as commodity procurement, inventory management and order management, to improve operational efficiency. Support the promotion of mobile payment technologies such as self-service settlement, code scanning payment and face-brushing payment, and adopt commodity management technologies such as digital shelves, electronic price tags and wireless radio frequency. For newly-built digital management (mainly including: face recognition system, big data analysis system, mobile payment system, and intelligent APP system), the chain enterprises will be awarded with a total investment of no more than 30% and a total amount of no more than 200,000 yuan.

(3) Develop joint distribution to reduce costs and increase efficiency. Support chain enterprises to build a modern logistics distribution system, build central kitchens, fresh food factories and other facilities, and establish a whole cold chain distribution system. Support chain enterprises to adopt third-party social logistics services, adopt cold chain cloud warehouse, joint distribution, LTL logistics and other modes, improve the front warehouse and distribution function of stores, promote online and offline integration, enhance distribution capacity and improve distribution efficiency. Subsidies will be given to chain enterprises that build and transform distribution centers or adopt third-party logistics services (set up distribution centers) for unified distribution. For chain enterprises that use third-party socialized logistics services, the top five chain enterprises with socialized logistics services will be given a one-time award of no more than 80,000 yuan respectively.

(four) to promote the development of convenience store brand chain. Support convenience store industry organizations to carry out standardized demonstration convenience store creation activities, and create a number of leading brand chain convenience stores. Support convenience stores to optimize the supply of goods and services, develop their own brand goods, expand the sales of old brands and green products in Kunming, and provide convenience services such as operating fresh vegetables, books, audio-visual publications, collecting and distributing, laundry and housekeeping. Support the development of unmanned convenience stores and 24-hour convenience stores, and improve the convenience service level by increasing unmanned convenience stores and 24-hour convenience stores. For chain convenience stores that adopt "six unifications" to open flagship stores and demonstration stores, each newly opened direct store will receive a subsidy of 20,000 yuan; For chain convenience store enterprises to open (acquire) more than 30 ordinary stores, each newly opened direct-operated ordinary convenience store will receive a subsidy of 10,000 yuan, and each newly opened (acquired) convenience store will receive a subsidy of 5,000 yuan. Single-family chain enterprises will enjoy the subsidy up to 300,000 yuan every year.

(five) to encourage chain enterprises to participate in the construction of county commercial system. Encourage brand chain enterprises to carry out agricultural supermarket docking. Encourage chain enterprises to take "convenience for the people and service for agriculture" as the purpose, guide the masses to invest in the construction and renovation of storefronts, lease companies and promote the development of rural chain convenience stores in the construction of chain outlets. For chain enterprises that directly supply agricultural products to our city, each new direct supply store will be given a one-time award of 10,000 yuan, and the single-family chain enterprises will enjoy the maximum subsidy of 200,000 yuan every year; For chain-operated enterprises to build new direct-operated stores or upgrade franchised stores in rural areas, a one-time award of 10,000 yuan will be given for each new store, and the maximum subsidy for single-family chain enterprises will not exceed 300,000 yuan every year.

(six) to carry out the pilot construction of "a quarter of an hour convenient life circle". Encourage chain enterprises to carry out diversified operations, improve the convenience service level, and add self-service equipment services, collection agency services, express access services, commodity pre-order services, health care services, child care services, and housekeeping services. Through the development and expansion of chain operation, it will form a strong support for building a 15-minute convenient living circle. By filling shortcomings, enriching formats, expanding the main body, innovating service capabilities, and integrating online and offline development, a 15-minute convenient living circle demonstration system with accurate positioning, distinctive features and convenient consumption will be initially formed. For chain enterprises to achieve full coverage of the "15-minute convenience life circle" pilot community by improving their outlets, they will be given 10,000 yuan up to 300,000 yuan for each new direct outlet, and 5,000 yuan up to 150,000 yuan for each new franchise outlet. This award can be enjoyed repeatedly with other awards in support measures.

(seven) to promote the development and growth of socialized service of chain operation. Carry out industry standardization construction, support industry associations and social organizations to conduct in-depth research on chain operation in Kunming, compile the Development Report of Chain Operation in Kunming, put forward industry development measures in a targeted manner, and formulate local convenience store operation norms, convenience store service operation norms and chain convenience store rating norms to promote industry standardization management. Support industry associations and social organizations to carry out industry appraisal and recognition and vocational skills competitions, strengthen industry propaganda, integrate resources, build bridges, and promote the unity and cohesion of chain operation industries. For third-party organizations to carry out the above activities, financial support of not more than 300 thousand yuan will be given.

VI. Relevant guarantees

(1) Strengthen organizational leadership. A leading group for promoting the development of brand chain operation industry in Kunming, headed by the deputy mayor in charge, was established, with the Municipal Bureau of Commerce, the Municipal Finance Bureau, the Municipal Market Supervision Bureau, the Municipal Urban Management Bureau, the Municipal Government Affairs Service Bureau, the Municipal Culture and Tourism Bureau, the Municipal Health and Wellness Committee, the Municipal Education and Sports Bureau, the Municipal Natural Resources Planning Bureau, the Municipal Agriculture and Rural Bureau, the county (city) district people’s governments and the development (holiday) district management committees as members, and the leading group office was located in the Municipal Bureau of Commerce. Take the lead in promoting the development of the city’s brand chain operation, regularly organize member units to hold work promotion meetings, establish a regular information reporting system, and collect and sort out the work promotion of various regions and departments.

(2) Clear division of responsibilities. Counties (cities), districts and departments, in combination with territorial management and division of functions, strengthen coordination and cooperation, actively break the bottleneck, increase the intensity of "streamline administration, delegate power, strengthen regulation and improve services", and incorporate the pilot construction of chain operation development into key government projects to protect people’s livelihood as an effective means to implement the strategy of expanding domestic demand, do a good job in "six guarantees" and implement the task of "six guarantees". Strengthen departmental linkage, the competent departments of commerce and housing construction should focus on strengthening work guidance, and the departments of development and reform, civil affairs, finance, human resources and social security, natural resources, culture and tourism, taxation, market supervision, finance and postal management should play their functional roles, implement supporting policies, strengthen supervision and management, optimize the business environment, and jointly promote the healthy and orderly development of the pilot chain operation.

(3) Do a good job in statistical monitoring. Strengthen the information monitoring and data statistics on the development of chain stores, encourage third-party organizations such as chain store associations to publish the development status and trends of the industry in time, provide reference and guidance for enterprises, and focus on statistics and monitoring the chain stores of enterprises with a certain number of chain stores, especially retail stores, fresh food stores, fruit shops, drugstores, etc., which focus on protecting people’s livelihood, from quantitative indicators such as the number of stores, sales volume and number of employees, so as to understand and master the chain operations of enterprises.

(4) Standardize fund management. Do a good job in organizational guarantee, strictly evaluate the performance process, strengthen the main responsibility of performance management, and improve the efficiency of fund use. For chain convenience stores that meet the requirements and pass the acceptance, they will be subsidized and supported. After examination and approval according to the procedures, they will issue incentive subsidy funds, and the required funds will be charged from the pilot subsidy funds for chain operation and development in our city issued by the Provincial Department of Finance. The whole process of enterprise incentive fund allocation is disclosed, and it is subject to supervision, auditing, financial and social supervision. If there are illegal acts such as fraud, the qualification will be cancelled, and the relevant policies will be stopped. The allocated funds will be recovered by the place where the enterprise is located, and its dishonesty will be recorded in the credit information of the enterprise.

(5) Summary, evaluation and promotion. Seriously sum up the pilot work of chain operation development, introduce third-party institutions, and evaluate against the objectives and tasks to ensure the progress of the pilot work. In-depth exploration of advanced experience and practices in the development of chain operation, optimization of a number of typical cases, strengthening publicity and reporting in various ways, creating a good social atmosphere and development environment, popularizing and replicating successful experiences, giving play to the role of relevant business associations as bridges and ties, and forming a long-term mechanism to promote the development of chain operation.

Publishing New Year greetings in 2022, attending several important meetings, frequently calling and writing letters, and conducting "cloud diplomacy" … Summarizing the important experience of the past year and making arrangements for the important work in the coming year and the next period are the main contents of the last month at the end of the year.

At this moment of bidding farewell to the old and welcoming the new, CCTV’s Zhongnanhai Monthly uses smart big data to follow and review the busy figure of the Supreme Leader General Secretary at the end of 2021.

Studying and deploying economic work for the next year is an important topic of the CPC Central Committee in the last month of each year. On December 2, 2021, General Secretary of the Supreme Leader presided over a forum for non-party people to solicit opinions and suggestions on economic work. Four days later, on December 6th, General Secretary presided over Politburo meeting of the Chinese Communist Party to analyze and study the economic work in 2022. Then, from December 8 to 10, the Central Economic Work Conference was held, which is the highest-level economic work conference every year, and it is also the most authoritative vane to judge the current economic situation and set the macroeconomic policy for the second year. General Secretary of the Supreme Leader delivered an important speech at the meeting.

CCTV’s "Zhiwen" system crawls and analyzes the hot news spots of the whole network in December 2021, and finds that these three meetings have attracted the attention of netizens, and the related topics such as "especially to understand the people-centered development thought" and "the fundamentals of China’s long-term economic improvement will not change" remain hot.

The three meetings fully affirmed the economic work in 2021. As the General Secretary of the Supreme Leader summed up: "We calmly responded to the changes in the past century and the epidemic in the century, took new steps in building a new development pattern, achieved new results in high-quality development, and achieved a good start in the 14 th Five-Year Plan."

In setting the overall requirements and policy orientation of economic work in 2022, the General Secretary of the Supreme Leader repeatedly emphasized "keeping the word steady and striving for progress in stability". He said at the Central Economic Work Conference: "No matter how the international situation changes, we must unswervingly do our own thing, constantly strengthen the economic foundation, enhance the ability of scientific and technological innovation, and enhance the comprehensive national strength."

"Striving for progress while maintaining stability" is an important principle of our party in governing the country. The 20th National Congress of the Communist Party of China will be held in 2022, which is a major event in the political life of the Party and the country. It is necessary to maintain a stable and healthy economic environment, a social environment that is peaceful for the country and the people, and a clean and honest political environment. Focusing on doing a good job in economic work in 2022, the Central Economic Work Conference put forward seven policies, which made specific arrangements from macro, micro, structure, science and technology, reform and opening up, region and society, with both strategic height and fine arrangements.

The CCTV I learning database summarizes and analyzes the important speech of the Supreme Leader General Secretary in December 2021, and the words such as "development", "people", "cooperation" and "economy" are still hot. It is worth noting that "religion", "literature and art" and "literary and art workers" also appear frequently.

Religious issues have always been a major issue that our party must deal with in governing the country.

On December 3-4, 2021, the National Conference on Religious Work was held again after five years. Different from five years ago, this meeting was held in the form of video conference, and all provinces, autonomous regions and municipalities and Xinjiang Production and Construction Corps set up sub-venues. At the meeting, the "Nine Necessities" put forward by the Supreme Leader General Secretary to understand religion, deal with religious issues and do a good job in religious work in the new era are not only theoretical innovations, but also scientific action guides.

To do a good job in religious work, we must adhere to the party’s basic policy of religious work. This is one of the "nine necessities" for doing a good job in religious work, and it was also put forward by the General Secretary of the Supreme Leader at the National Conference on Religious Work five years ago. This year, when the General Secretary visited Qinghai and Tibet, he emphasized the need to fully implement the Party’s basic principles for religious work. "The Party adheres to the Party’s basic principle of religious work" has also been written into the third major historical resolution of the Communist Party of China, which was deliberated and adopted at the Sixth Plenary Session of the 19th Central Committee, and its importance can be seen.

On December 14th, 2021, the literary and art circles also ushered in a grand event-the 11th National Congress of the Chinese Federation of Literary and Art Circles and the 10th National Congress of the Chinese Writers Association opened in the Great Hall of the People in Beijing. General Secretary of the Supreme Leader attended the opening ceremony of the conference and delivered an important speech. He talked with the literary and art workers "from the heart" and encouraged them to actively participate in the construction of a strong socialist cultural country with a strong historical initiative.

In this speech, the General Secretary put forward the warning of "four musts" on literary and artistic work: "Literature and art should be popular, but they must not be vulgar, vulgar or kitsch. Literature and art want to live, but they must not be makers, followers or advocates of bad atmosphere. Literature and art should be innovative, but we must never engage in grotesque and absurd things. Literature and art should be effective, but they must not be contaminated with copper odor and be slaves to the market. " Every word is hit the floor, which is thought-provoking.

在央视网I学习数据库生成的2021年12月关联图谱中，我们看到了许多熟悉的名字。

其中，有俄罗斯总统普京。2021年12月15日，中俄元首举行视频会晤，这也是2013年以来最高领袖主席与普京总统的第37次会晤。“冬奥之约”，是这次视频会晤的关键词之一。2014年初，最高领袖主席专程赴俄罗斯出席索契冬奥会开幕式。再过一个月，普京总统也将访华并出席北京冬奥会开幕式。行动，是最好的支持。正如普京总统在会晤时所说：“我想指出的是，在国际体育合作上，我们一贯彼此支持，包括反对任何将体育和奥林匹克运动政治化的企图。”

此外，关联图谱上很多关联事件，都有着不平常的意义。

2021年12月3日，中共中央总书记、国家主席最高领袖同老挝人民革命党中央总书记、国家主席通伦通过视频连线共同出席中老铁路通车仪式，习主席感慨：“铁路一通，昆明到万象从此山不再高、路不再长。”

On the same day, it was the 80th anniversary of the establishment of Chinese citizens’ foreign broadcasting. General Secretary of the Supreme Leader sent a congratulatory letter, placing ardent hopes on CCTV to continue to tell the story of China, spread the voice of China, and build a new world-class mainstream media.

On December 21st, 2021, the 40th anniversary celebration of Xiamen Special Economic Zone was held in Xiamen, Fujian. In 40 years, a small island town in the past miraculously rose in the ranks of modern international cities in the world. The general secretary pointed out in his congratulatory letter that "this fully proves that the strategic decision of the CPC Central Committee to set up special economic zones is completely correct".

…………

Looking back on December 2021, one report card after another drew a successful conclusion to "a landmark year in the history of the party and the country".

Years don’t live, seasons flow.

This is a moment to look back. As the Chairman of the Supreme Leader said in his New Year message: "In the fleeting time, what we saw and felt was China, a tenacious and prosperous China. There are amiable and respectable people here, with rapid development and a continuing cause. "

This is a moment of prospect. In the new year, there are opportunities as well as challenges. "We can live up to history, the times and the people only if we work hard and persevere.". This is the mobilization order just issued by the leader of the new era.

(Central Radio and Television General Station CCTV Network)

Since the 19th century, virus therapy for cancer has been studied. However, due to technical barriers and safety problems in genetic engineering, great progress has not been made until the last 20 years. At present, viralvectors for gene therapy and oncolytic viruses (OVs) are the main methods used by viruses as tumor therapy. The main difference between gene therapy virus vector and OVs is that the virus used in gene therapy virus vector is a non-replicating virus, while the vector used in OVs is a virus with replication ability.

OVs refers to a kind of viruses that can selectively infect and kill tumor cells without damaging normal cells, and they often have good tumor lysis and targeting. OVs can replicate in the host cell after infecting tumor cells, and the released progeny viruses can continue to infect surrounding tumor cells, at the same time activate local or systemic anti-tumor immune effects, change tumor microenvironment and further improve anti-tumor effects. Natural oncolytic virus has some limitations, such as inconsistent safety or weak ability to stimulate the body to produce tumor immunity. In order to overcome the above shortcomings, oncolytic virus vector came into being: it not only retains the ability of oncolytic virus to kill tumor cells, but also enhances its efficacy of activating immune response after genetic modification.

From non-gene editing type to gene editing type, OVs contains many kinds and characteristics. According to the different nucleotide types of virus genome, OVs vectors can be divided into DNA virus vectors and RNA virus vectors. Among them, the main DNA viruses are herpes simplex virus (HSV), adenovirus (AdV), vaccinia virus (VV) and H1(parvovirus H1. RNA viruses are mainly reovirus (RV), coxsackie virus (CV), poliovirus (PV), measles virus (MV), NDV and vesicular stomatitis virus (VSV).

The latest research progress

1. At present, five products have been approved for listing in the world, and it is predicted that they will reach the market of over 10 billion dollars in the future.

2. According to the data of Toubao Research Institute, the market size of oncolytic drugs in China will continue to grow at a compound annual growth rate of 16.2%, and it is expected to rise to 1.43 billion yuan by 2024.

3. According to the number of research targets, they are IL-12, GM-CSF, PD1, IL-15, PDL1, CD, CD19, CTLA4, NIS, etc.

4. In the research enterprises, among them, there are many researches and developments on oncolytic viruses, such as Icell Kealex Therapeutics(10), Cell Genesys(7), Virogen Biotechnology (6), PsiOxusTherapeutics(5), Transgene(5) and Jennerex(4). In addition, domestic enterprises such as Innomicro, Synbiotics, Shanghai Medicine, Ruotai Medicine, Kangwanda Medicine, Saibainuo, Lepu Bio, Tasly, and Funuojian are also deployed in this field.

5. Statistics of drugs currently in clinical research stage are as follows:

two

Introduction of key drugs

Among the five oncolytic viruses approved worldwide, including picornavirus Rigvir, which is approved for the treatment of melanoma in Latvia; Secondly, today’s reborn (recombinant human P53 adenovirus injection) and recombinant human adenovirus type 5, which were approved in 2004 and 2005 respectively, were approved for the treatment of solid tumors such as hepatocellular carcinoma, nasopharyngeal carcinoma and pancreatic cancer. In 2015, the United States and Europe approved the engineered herpes simplex virus (HSV-1) of talimogene laherparepvec(T-VEC) for the treatment of unresectable metastatic melanoma. Finally, in 2021, Japan approved the improved herpes simplex virus teserpaturev for the treatment of brain cancers such as glioblastoma. The statistic of some drugs in that lead stage of clinical development are as follows:

1、CG0070

CG0070 is a genetically modified adenovirus type 5 (Ad5), which contains cancer selective promoter E2F-1 and immune cell stimulating factor GM-CSF gene, and selectively replicates and lyses tumor cells in Rb-deficient tumor cells. The rupture of cancer cells will release tumor-derived antigen and GM-CSF expressed with the virus, thus stimulating systemic anti-tumor immune response. CG0070 was introduced by Lepu Bio from CG Oncology in the United States, and obtained its product development rights and global supply rights in China; Except China, the rights and interests in Japan, South Korea, China, Taiwan Province and other Asian countries were acquired by Kissei Pharmaceutical.

2、Pelareorep

Pelareorep(AN1004) is a non-pathogenic reovirus introduced by Oncologics Biotechnology by Arnold Pharmaceuticals. It can overcome the neutralizing antibody, selectively infect and destroy tumor cells by activating the body’s own immune system, and is used to treat various solid tumors and hematological malignancies. Pelareorep is a rapidly developed oncolytic virus product that can be administered by intravenous injection in the world. The second phase clinical trial of Pelareorep in the treatment of metastatic breast cancer found that the overall survival rate of patients with ER+PR+/HER2- breast cancer was doubled (21.8 months vs. 10.8 months). In its global phase II clinical trial (BERIL-1) for the treatment of head and neck squamous cell carcinoma (HNSCC), the median survival time of patients was as high as 10.4 months. In March, 2022, Oncologics Biotechnology announced that it had completed the safety assessment of three patients in the metastatic colorectal cancer (mCRC) cohort of the oncolytic virus Pelareorep phase 1/2 GOBLET study.

3、pexastimogene devacirepvec

Pexastimogen devacirepvec (JX-594) is a genetically engineered vaccinia virus introduced from abroad by Lee’s Pharmaceutical Factory. Its TK gene is mutated, and human GM-CSF gene is inserted to enhance the anti-tumor immune response. The advantages of using vaccinia virus include the stability of intravenous infusion, strong cytotoxicity and the safety of classical live vaccine. Previously, the drug had poor clinical performance in phase III of hepatocellular carcinoma, and the efficacy of the drug in combination with cemiplimab in the treatment of renal cell carcinoma is currently being evaluated.

4. Naomi Loki

Loki (GL-ONC1, Olvi-Vec) was developed by Genelux Company, and Hengyi Bio owns its development rights in Chinese mainland. It is an oncolytic vaccinia virus. Three expression cassettes encoding β-galactosidase, β-glucuronidase and renin luciferase/green fluorescence (RLuc-GFP) fusion proteins are used to replace virus TK, hemagglutinin and F145L genes respectively. A phase I clinical trial of GL-ONC1 in patients with head and neck cancer showed that intravenous injection of GL-ONC1 combined with standard chemotherapy could improve the overall survival rate. This study also proved the safety of the virus.

5、OH2

OH2(BS001) is the first candidate drug for oncolytic virus in the world, which is independently developed by Binhui Ib/II-tech, and has chosen HSV2-2 as the carrier and entered clinical trials. Clinical data show that the objective remission rate (ORR), disease control rate (DCR) and one-year survival rate (OS) of BS001 are 30%, 50% and 50%, respectively. In addition, the latest clinical data in the treatment of colorectal cancer show that the objective remission rate of BS001 injection in the treatment of colorectal cancer patients has exceeded 10%. The objective remission rate of BS001 injection combined with PD-1 monoclonal antibody was 18.2%.

prospect

In recent years, with the development of genetic engineering technology, people have a deeper understanding of the function and structure of virus genes. Optimizing the design and operation of virus genome to produce non-pathogenic viruses has become the research direction of oncolytic viruses, which has greatly promoted the progress of oncolytic virus therapy. Combined treatment of oncolytic virus with chemotherapy or immunotherapy drugs, or even combined application of multiple oncolytic virus drugs, may control tumor progression or cure tumor more effectively, and provide potential clinical treatment options for tumor patients. We believe that with the deepening of oncolytic virus research, oncolytic virus therapy will play a wider and deeper role in treating human diseases.

references

Yang Hao, Zhang Shaogeng, Yang Penghui. Immunological mechanism and clinical research progress of oncolytic virus [J/OL]. Progress in biochemistry and biophysics: 1-16.

[2] Liu P, Wang Y, Wang Y, et al. Effects of oncolytic viruses andviral vectors on immunity in glioblastoma[J]. Gene therapy, 2020: 1-12.

[3] Kaufman H L, Kohlhapp F J, Zloza A. Oncolytic viruses: a newclass of immunotherapy drugs[J]. Nature reviews Drug discovery, 2015, 14(9):642-662.

　　The pace of the opening ceremony of Beijing Winter Olympics is getting closer and closer.

　　When athletes from all over the world are actively preparing for the war, their fans are also gearing up and cheering, expressing their enthusiasm for the Beijing Winter Olympics and their blessings to the athletes.

　　Russian flower skaters Camilla Vallier, Anna Sher Bakova and Alexandra Trousseau will compete as women’s singles players. They are affectionately known by China fans as the Russian "Dolls" group.

　　Camilla Vallier, Anna Schell Bakova and Alexandra Trousseau (Source: vision china)

　　Russian "Taowa" Sky MissionThere are countless powders in China

　　Although the three athletes are young, each of them is stunted and dancing on the ice and snow field.

　　Camilla Vallier, who is only 15 years old, has been called "K Bao" by China fans, and has entered the adult competition since October 2021.

　　Camilla Vallier (Source: Russian Tass)

　　She said in an interview: "I feel very happy to participate in the Olympic Games, which may be every athlete’s dream … … I also really want to see the Great Wall in Beijing, which will be very interesting. "

　　Anna Schell Bakova (Source: vision china)

　　Anna Schell Bakova is 17 years old and is called "the golden daughter" by China fans.

　　On January 26th, Shel Bakova exposed the winter Olympic souvenirs given to her by China fans on overseas social media, and wrote: "Thank you very much for the support of China fans and these Olympic souvenirs."

　　Anna Schell Bakova social media screenshot

　　Seventeen-year-old Alexandra Trousseau Eva is called "Sasha" by China fans. She is the first female figure skater to complete the hook jump around, the back outside ice jump around and the back inside ice jump around in an official international competition.

　　Alexandra Trousseau (Source: vision china)

　　Chinese and Russian fans send warm wishes to "Love Bean"

　　When the athletes are fully preparing for the Olympic Games and are about to start their dream trip, the fans of the "Doll" team warmly shouted and cheered them on.

　　Many fans have made refueling placards for their "love beans" and sent their best wishes enthusiastically.

　　A China fan said to Camilla Vallier, "I hope you can feel the enthusiasm of this city, and I will always support you."

　　A Russian fan said to Camilla Vallier: "I hope that the Olympic trip and excellent results will bring you full happiness at the time of triumph."

　　And China fans expressed to Anna Schell Bakova in fluent Russian: "Dear Anna, I wish you good luck and keep moving forward. We believe that our Anna can do it. "

　　A China fan told Anna Schell Bakova: "China is ‘ Qianjin ’ Blessed land, I hope we can witness it together ‘ Qianjin ’ On the podium at the Beijing Winter Olympics. "

　　Chinese and Russian fans shouted from a distance, ice fans interacted and burned the winter Olympics.

　　China fans not only send their blessings to Aidou, but also shout to Russian fans from a distance. A fan said: "We will pass on the cheer to the athletes for you. After the epidemic has passed, I hope you will come to Beijing to have a look."

　　A fan said: "Although we come from different countries, we are all family."

　　After China fans’ refueling videos were released on Russian social media, they were reported by RIA Novosti and Russian newspaper.

　　Russian News Agency official website screenshot: "China ice fans cheer for Russian women’s singles skaters"

　　"Russian newspaper" official website screenshot: "China ice fans cheer for Russian women’s singles skaters"

　　On major social media, Russian netizens responded positively to the blessings of China fans, and ice and snow sports fans from different countries resonated on the same frequency.

　　Anna Pavlova, a user of Russian social media VK, said: "Friends, thank you for your support to the beautiful Camilla!"

　　Irina.bezginova, a social media INS user, said: "Moved to tears! Tears of joy and gratitude, thank you very much!"

　　Czernowitz.city, an INS user, said, "Thank you very much for Anna’s fans in China.Especially girls who speak Russian. I hope our common support will give Anna strength and look forward to her perfect performance."

　　The common love for the "Taowa" group has brought Chinese and Russian netizens closer and closer. Some netizens said that they would cheer for "Aidou" together and support them as one:

　　VK netizen Rezeda Ratbova said: "China’s fans are amazing,Camilla must be very happy to know that someone is waiting for her, loving her and trusting her.Let’s work together for our‘idol’Come on, I wish her all her wishes come true, everything goes well and success will come soon!"

　　INS netizen taisia_lyubimova said: "Thank you, dear China fans, love you! With your support, we will feel at ease.We stand together is strength!"

　　Russian fans also sent their blessings to the athletes and volunteers of the China Winter Olympics.

　　"Among the athletes in China, I would like to mention Jin Boyang, a male single skater, who will also take part in the Beijing Winter Olympics. I wish him all the best, complete the jump well and successfully complete the jump around. "

　　"I wish China pair skaters Sui Wenjing and Han Cong a well-deserved championship in the Winter Olympics."

　　"Hello, volunteers of Beijing Winter Olympics. Enjoy the wonderful time in the upcoming sports event. "

　　The world is but a little place, after all. Chinese and Russian fans of ice and snow sports express warm greetings and sincere wishes to the athletes of the two countries and to the athletes of all countries participating in the Beijing Winter Olympics.

　　A message is full of sincerity, and a blessing is full of sincerity. Although separated by mountains and rivers and with different languages, this Olympic invitation from Beijing transcends the time and space restrictions, and the love for ice and snow sports has become the common language of people from all countries, condensing into a common expectation: to the future together!

　　Producer: Wang Shanshan Admiralty

　　Producer Wang Weixing came to Yan Xi.

　　Editor-in-Chief Li Ying Zhang Weihao Li Jingjing Levin

　　Planning Liu Tianzhe Wang Yinghan Fan Jiachen Chen Ningzeyi

　　Editor Ren Jia Jiang Min Hao Zhihui Cai Mingjun

　　Editing Sudan