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Since the 19th century, virus therapy for cancer has been studied. However, due to technical barriers and safety problems in genetic engineering, great progress has not been made until the last 20 years. At present, viralvectors for gene therapy and oncolytic viruses (OVs) are the main methods used by viruses as tumor therapy. The main difference between gene therapy virus vector and OVs is that the virus used in gene therapy virus vector is a non-replicating virus, while the vector used in OVs is a virus with replication ability.

OVs refers to a kind of viruses that can selectively infect and kill tumor cells without damaging normal cells, and they often have good tumor lysis and targeting. OVs can replicate in the host cell after infecting tumor cells, and the released progeny viruses can continue to infect surrounding tumor cells, at the same time activate local or systemic anti-tumor immune effects, change tumor microenvironment and further improve anti-tumor effects. Natural oncolytic virus has some limitations, such as inconsistent safety or weak ability to stimulate the body to produce tumor immunity. In order to overcome the above shortcomings, oncolytic virus vector came into being: it not only retains the ability of oncolytic virus to kill tumor cells, but also enhances its efficacy of activating immune response after genetic modification.

From non-gene editing type to gene editing type, OVs contains many kinds and characteristics. According to the different nucleotide types of virus genome, OVs vectors can be divided into DNA virus vectors and RNA virus vectors. Among them, the main DNA viruses are herpes simplex virus (HSV), adenovirus (AdV), vaccinia virus (VV) and H1(parvovirus H1. RNA viruses are mainly reovirus (RV), coxsackie virus (CV), poliovirus (PV), measles virus (MV), NDV and vesicular stomatitis virus (VSV).

The latest research progress

1. At present, five products have been approved for listing in the world, and it is predicted that they will reach the market of over 10 billion dollars in the future.

2. According to the data of Toubao Research Institute, the market size of oncolytic drugs in China will continue to grow at a compound annual growth rate of 16.2%, and it is expected to rise to 1.43 billion yuan by 2024.

3. According to the number of research targets, they are IL-12, GM-CSF, PD1, IL-15, PDL1, CD, CD19, CTLA4, NIS, etc.

4. In the research enterprises, among them, there are many researches and developments on oncolytic viruses, such as Icell Kealex Therapeutics(10), Cell Genesys(7), Virogen Biotechnology (6), PsiOxusTherapeutics(5), Transgene(5) and Jennerex(4). In addition, domestic enterprises such as Innomicro, Synbiotics, Shanghai Medicine, Ruotai Medicine, Kangwanda Medicine, Saibainuo, Lepu Bio, Tasly, and Funuojian are also deployed in this field.

5. Statistics of drugs currently in clinical research stage are as follows:

two

Introduction of key drugs

Among the five oncolytic viruses approved worldwide, including picornavirus Rigvir, which is approved for the treatment of melanoma in Latvia; Secondly, today’s reborn (recombinant human P53 adenovirus injection) and recombinant human adenovirus type 5, which were approved in 2004 and 2005 respectively, were approved for the treatment of solid tumors such as hepatocellular carcinoma, nasopharyngeal carcinoma and pancreatic cancer. In 2015, the United States and Europe approved the engineered herpes simplex virus (HSV-1) of talimogene laherparepvec(T-VEC) for the treatment of unresectable metastatic melanoma. Finally, in 2021, Japan approved the improved herpes simplex virus teserpaturev for the treatment of brain cancers such as glioblastoma. The statistic of some drugs in that lead stage of clinical development are as follows:

1、CG0070

CG0070 is a genetically modified adenovirus type 5 (Ad5), which contains cancer selective promoter E2F-1 and immune cell stimulating factor GM-CSF gene, and selectively replicates and lyses tumor cells in Rb-deficient tumor cells. The rupture of cancer cells will release tumor-derived antigen and GM-CSF expressed with the virus, thus stimulating systemic anti-tumor immune response. CG0070 was introduced by Lepu Bio from CG Oncology in the United States, and obtained its product development rights and global supply rights in China; Except China, the rights and interests in Japan, South Korea, China, Taiwan Province and other Asian countries were acquired by Kissei Pharmaceutical.

2、Pelareorep

Pelareorep(AN1004) is a non-pathogenic reovirus introduced by Oncologics Biotechnology by Arnold Pharmaceuticals. It can overcome the neutralizing antibody, selectively infect and destroy tumor cells by activating the body’s own immune system, and is used to treat various solid tumors and hematological malignancies. Pelareorep is a rapidly developed oncolytic virus product that can be administered by intravenous injection in the world. The second phase clinical trial of Pelareorep in the treatment of metastatic breast cancer found that the overall survival rate of patients with ER+PR+/HER2- breast cancer was doubled (21.8 months vs. 10.8 months). In its global phase II clinical trial (BERIL-1) for the treatment of head and neck squamous cell carcinoma (HNSCC), the median survival time of patients was as high as 10.4 months. In March, 2022, Oncologics Biotechnology announced that it had completed the safety assessment of three patients in the metastatic colorectal cancer (mCRC) cohort of the oncolytic virus Pelareorep phase 1/2 GOBLET study.

3、pexastimogene devacirepvec

Pexastimogen devacirepvec (JX-594) is a genetically engineered vaccinia virus introduced from abroad by Lee’s Pharmaceutical Factory. Its TK gene is mutated, and human GM-CSF gene is inserted to enhance the anti-tumor immune response. The advantages of using vaccinia virus include the stability of intravenous infusion, strong cytotoxicity and the safety of classical live vaccine. Previously, the drug had poor clinical performance in phase III of hepatocellular carcinoma, and the efficacy of the drug in combination with cemiplimab in the treatment of renal cell carcinoma is currently being evaluated.

4. Naomi Loki

Loki (GL-ONC1, Olvi-Vec) was developed by Genelux Company, and Hengyi Bio owns its development rights in Chinese mainland. It is an oncolytic vaccinia virus. Three expression cassettes encoding β-galactosidase, β-glucuronidase and renin luciferase/green fluorescence (RLuc-GFP) fusion proteins are used to replace virus TK, hemagglutinin and F145L genes respectively. A phase I clinical trial of GL-ONC1 in patients with head and neck cancer showed that intravenous injection of GL-ONC1 combined with standard chemotherapy could improve the overall survival rate. This study also proved the safety of the virus.

5、OH2

OH2(BS001) is the first candidate drug for oncolytic virus in the world, which is independently developed by Binhui Ib/II-tech, and has chosen HSV2-2 as the carrier and entered clinical trials. Clinical data show that the objective remission rate (ORR), disease control rate (DCR) and one-year survival rate (OS) of BS001 are 30%, 50% and 50%, respectively. In addition, the latest clinical data in the treatment of colorectal cancer show that the objective remission rate of BS001 injection in the treatment of colorectal cancer patients has exceeded 10%. The objective remission rate of BS001 injection combined with PD-1 monoclonal antibody was 18.2%.

prospect

In recent years, with the development of genetic engineering technology, people have a deeper understanding of the function and structure of virus genes. Optimizing the design and operation of virus genome to produce non-pathogenic viruses has become the research direction of oncolytic viruses, which has greatly promoted the progress of oncolytic virus therapy. Combined treatment of oncolytic virus with chemotherapy or immunotherapy drugs, or even combined application of multiple oncolytic virus drugs, may control tumor progression or cure tumor more effectively, and provide potential clinical treatment options for tumor patients. We believe that with the deepening of oncolytic virus research, oncolytic virus therapy will play a wider and deeper role in treating human diseases.

references

Yang Hao, Zhang Shaogeng, Yang Penghui. Immunological mechanism and clinical research progress of oncolytic virus [J/OL]. Progress in biochemistry and biophysics: 1-16.

[2] Liu P, Wang Y, Wang Y, et al. Effects of oncolytic viruses andviral vectors on immunity in glioblastoma[J]. Gene therapy, 2020: 1-12.

[3] Kaufman H L, Kohlhapp F J, Zloza A. Oncolytic viruses: a newclass of immunotherapy drugs[J]. Nature reviews Drug discovery, 2015, 14(9):642-662.

　　The pace of the opening ceremony of Beijing Winter Olympics is getting closer and closer.

　　When athletes from all over the world are actively preparing for the war, their fans are also gearing up and cheering, expressing their enthusiasm for the Beijing Winter Olympics and their blessings to the athletes.

　　Russian flower skaters Camilla Vallier, Anna Sher Bakova and Alexandra Trousseau will compete as women’s singles players. They are affectionately known by China fans as the Russian "Dolls" group.

　　Camilla Vallier, Anna Schell Bakova and Alexandra Trousseau (Source: vision china)

　　Russian "Taowa" Sky MissionThere are countless powders in China

　　Although the three athletes are young, each of them is stunted and dancing on the ice and snow field.

　　Camilla Vallier, who is only 15 years old, has been called "K Bao" by China fans, and has entered the adult competition since October 2021.

　　Camilla Vallier (Source: Russian Tass)

　　She said in an interview: "I feel very happy to participate in the Olympic Games, which may be every athlete’s dream … … I also really want to see the Great Wall in Beijing, which will be very interesting. "

　　Anna Schell Bakova (Source: vision china)

　　Anna Schell Bakova is 17 years old and is called "the golden daughter" by China fans.

　　On January 26th, Shel Bakova exposed the winter Olympic souvenirs given to her by China fans on overseas social media, and wrote: "Thank you very much for the support of China fans and these Olympic souvenirs."

　　Anna Schell Bakova social media screenshot

　　Seventeen-year-old Alexandra Trousseau Eva is called "Sasha" by China fans. She is the first female figure skater to complete the hook jump around, the back outside ice jump around and the back inside ice jump around in an official international competition.

　　Alexandra Trousseau (Source: vision china)

　　Chinese and Russian fans send warm wishes to "Love Bean"

　　When the athletes are fully preparing for the Olympic Games and are about to start their dream trip, the fans of the "Doll" team warmly shouted and cheered them on.

　　Many fans have made refueling placards for their "love beans" and sent their best wishes enthusiastically.

　　A China fan said to Camilla Vallier, "I hope you can feel the enthusiasm of this city, and I will always support you."

　　A Russian fan said to Camilla Vallier: "I hope that the Olympic trip and excellent results will bring you full happiness at the time of triumph."

　　And China fans expressed to Anna Schell Bakova in fluent Russian: "Dear Anna, I wish you good luck and keep moving forward. We believe that our Anna can do it. "

　　A China fan told Anna Schell Bakova: "China is ‘ Qianjin ’ Blessed land, I hope we can witness it together ‘ Qianjin ’ On the podium at the Beijing Winter Olympics. "

　　Chinese and Russian fans shouted from a distance, ice fans interacted and burned the winter Olympics.

　　China fans not only send their blessings to Aidou, but also shout to Russian fans from a distance. A fan said: "We will pass on the cheer to the athletes for you. After the epidemic has passed, I hope you will come to Beijing to have a look."

　　A fan said: "Although we come from different countries, we are all family."

　　After China fans’ refueling videos were released on Russian social media, they were reported by RIA Novosti and Russian newspaper.

　　Russian News Agency official website screenshot: "China ice fans cheer for Russian women’s singles skaters"

　　"Russian newspaper" official website screenshot: "China ice fans cheer for Russian women’s singles skaters"

　　On major social media, Russian netizens responded positively to the blessings of China fans, and ice and snow sports fans from different countries resonated on the same frequency.

　　Anna Pavlova, a user of Russian social media VK, said: "Friends, thank you for your support to the beautiful Camilla!"

　　Irina.bezginova, a social media INS user, said: "Moved to tears! Tears of joy and gratitude, thank you very much!"

　　Czernowitz.city, an INS user, said, "Thank you very much for Anna’s fans in China.Especially girls who speak Russian. I hope our common support will give Anna strength and look forward to her perfect performance."

　　The common love for the "Taowa" group has brought Chinese and Russian netizens closer and closer. Some netizens said that they would cheer for "Aidou" together and support them as one:

　　VK netizen Rezeda Ratbova said: "China’s fans are amazing,Camilla must be very happy to know that someone is waiting for her, loving her and trusting her.Let’s work together for our‘idol’Come on, I wish her all her wishes come true, everything goes well and success will come soon!"

　　INS netizen taisia_lyubimova said: "Thank you, dear China fans, love you! With your support, we will feel at ease.We stand together is strength!"

　　Russian fans also sent their blessings to the athletes and volunteers of the China Winter Olympics.

　　"Among the athletes in China, I would like to mention Jin Boyang, a male single skater, who will also take part in the Beijing Winter Olympics. I wish him all the best, complete the jump well and successfully complete the jump around. "

　　"I wish China pair skaters Sui Wenjing and Han Cong a well-deserved championship in the Winter Olympics."

　　"Hello, volunteers of Beijing Winter Olympics. Enjoy the wonderful time in the upcoming sports event. "

　　The world is but a little place, after all. Chinese and Russian fans of ice and snow sports express warm greetings and sincere wishes to the athletes of the two countries and to the athletes of all countries participating in the Beijing Winter Olympics.

　　A message is full of sincerity, and a blessing is full of sincerity. Although separated by mountains and rivers and with different languages, this Olympic invitation from Beijing transcends the time and space restrictions, and the love for ice and snow sports has become the common language of people from all countries, condensing into a common expectation: to the future together!

　　Producer: Wang Shanshan Admiralty

　　Producer Wang Weixing came to Yan Xi.

　　Editor-in-Chief Li Ying Zhang Weihao Li Jingjing Levin

　　Planning Liu Tianzhe Wang Yinghan Fan Jiachen Chen Ningzeyi

　　Editor Ren Jia Jiang Min Hao Zhihui Cai Mingjun

　　Editing Sudan

Special feature of 1905 film network With the desk corner calendar book from fullness to thinness, 2019 entered the final countdown.

When people are typing at their desks for personal year-end summary, 1905 Data Institute made an annual survey report for China film market in 2019. This report tries to present the overall situation and development trend of China film market in 2019 from the dimensions of market, word of mouth and phenomenon.

Click to browse the full version of 2019 China Film Survey Report.

Behind the record high box office and movie attendance in the whole year, it is inseparable from the two-way maturity of the audience and the market. The increasingly mature public aesthetic makes the symbiotic relationship between word-of-mouth and box office closer. The industrial traces in domestic movies are gradually increasing, which opens the first year of domestic sci-fi movies, and (hereinafter referred to as "Nezha") writes a new chapter in the rise of the country.

Market article

Box office hit a new high, with domestic films as the main force.

In 2019, the annual box office and movie attendance of China film market reached a new high, which became an important part of the development of the global film industry.The quality of domestic films has improved steadily, and the box office output capacity of head films is amazing.

According to the market section of the survey report, the annual box office of China film market reached 64.266 billion in 2019, an increase of 5.4% compared with 2018; The total number of people watching movies in urban cinemas reached 1.727 billion.

Among them, the cumulative total box office of domestic films was 41.175 billion, an increase of 8.65% compared with 2018, accounting for 64.07% of the box office in 2019.

In the key node of breaking 10 billion, domestic films have played an important role.During the Spring Festival, domestic blockbusters such as The Wandering Earth, Japan and South Korea helped the box office of China film market break through the first 10 billion mark. On the time axis, it is 8 days ahead of the same achievement in 2018.

On the day of the Spring Festival (February 5), the single-day box office reached 1.449 billion, setting a new record for the single-day box office in mainland film history. Thanks to the Spring Festival, the box office of China film market reached 11.157 billion in February, an increase of 9.45% compared with 2018. This box office achievement is not only the highest monthly box office in mainland film history, but also the "roof of the world" in global film history.

During the summer file in 2019, domestic films once again refreshed the audience’s past cognition. The adult-oriented animated film Nezha, which is suitable for all ages, is popular all over the country, breaking the prejudice that the box office limit of domestic animated films will not exceed 3 billion. In the end, the box office of this film broke through the 5 billion mark and became the annual box office champion in 2019. At the same time, the film also won the second place in the box office list of mainland film history.

When Nezha surpassed The Wandering Earth at the box office, Frant Gwo director Weibo sent a message "Little Nezha, it’s your turn" with full blessings.Appreciate each other among China filmmakers is touching.More outstanding young film talents are showing their talents. The creation of domestic films shows the trend of a hundred battles.

The National Day stalls presented the "Three Masters",,, and presented an audio-visual feast with rich dishes to the audience.Under the leadership of three box office champion seed players, the cumulative box office in 2019 was 5.133 billion, an increase of 135.89% year-on-year.

My People，My Country, who broke the traditional main melody film creation structure, showed the audience the unity behind the 70th anniversary of the founding of New China through seven story paragraphs with the most characteristics of the times.In the end, the film ranked fourth in the annual box office list with a score of 3.119 billion.

In 2019, domestic films were well-deserved protagonists in the mainland film market. Behind the record box office and movie attendance in the whole year, the number of domestic screens and the total number of screenings also reached a new high.According to statistics, in 2019, the total number of domestic screens reached 69,787, with an increase of 9,708. The infrastructure construction of China film market is in the forefront of the world.

Word of mouth

The audience’s aesthetic appreciation is improved, and there is nowhere to hide bad movies.

The symbiotic relationship between word-of-mouth and box office is becoming more and more mature, which has become one of the most remarkable features of China film market in 2019. The content is that the era of kings has arrived, and everyone is shouting at bad movies.

In 1905, the School of Data selected the top ten Chinese movies in 2019 through the votes of film critics and audiences. The statistical results of these two surveys show that word-of-mouth has become the main influencing factor of box office trend.

Nezha is at the top of the top ten list of word-of-mouth of both film critics and ordinary audiences. The explosion of word-of-mouth in the early stage made the film decide to file for release. This film has performed well in scoring platforms with obvious differences in audience groups such as Douban and Lighthouse.

According to statistics, on the Douban platform, which is dominated by veteran fans, there are more than 1.17 million people scoring this film, with an average score of 8.5; On the lighthouse platform dominated by ordinary audiences, there were more than 3.94 million people scoring the film, with an average score of 9.5.

The Wandering Earth and My People，My Country, whose two lists overlap, performed well in different scoring platforms. The cumulative box office of these films is mostly located in the TOP10 list of the annual box office of the mainland film market in 2019.

The overall improvement of domestic audience’s aesthetic ability has become the main reason for the convergence of word-of-mouth and box office performance. In the fast-paced modern life, the time cost of watching a movie is often greater than the material cost.The audience’s pursuit of the quality of the film tends to be strict. In the past, the explosive production mode of traffic star+big IP has become a thing of the past.

In 2019, regardless of Chinese and foreign movies, the box office trend was less than expected. The box office of these films runs counter to the production cost, mostly because the content quality is not good enough. The audience’s improving aesthetic ability has continuously compressed the living space of bad films, and the overall market environment has developed in a benign direction.

In today’s China film market, "those who get the content get the word of mouth, and those who get the word of mouth get the box office", and the creators of film and television works with craftsman spirit usher in the best era. In the future, China film market will also welcome those high-quality big-screen works, which makes people look forward to it.

Phenomena and industries

The new atmosphere behind the annual keywords

In 2019, behind the positive growth of various data in China film market, many new industries have emerged. Industrialization, the rise of the country, and the announcement of new tricks have become the core keywords for the development of the domestic film market in 2019.

As we all know, science fiction film and animated film shooting can best test a country’s film industrialization level. This kind of film needs a lot of visual effects to create a different sense of space and world view for the audience.The quantity and quality of special effects constitute the foundation of superstructure.

It is reported that there are 2,003 special effects shots in The Wandering Earth’s whole film, and it is normal for a shot to be revised more than 100 times from the first edition to the final draft. According to director Frant Gwo, more than 75% of the special effects shots in this film were produced by China Company.

The filming of the animated film "Nezha" took five years from planning to release, and 66 script versions were run in. There are 1,800 shots in the whole film, with more than 1,400 special effects shots, which is the most animated film in China over the years.

In addition to the increasingly obvious traces of industrialization, film marketing also keeps pace with the times and presents new tricks. In the economic era of online celebrity, everything can be brought.Domestic filmIt was the first time to open the preferential qualification certificate for live movies with goods. Since then, films such as "The Station of the Southern Party" have followed suit.

As a word-of-mouth pre-pointing marketing strategy, it has entered the era of segmentation. During the summer file, the first-tier cities in Beijing, Guangzhou and Shenzhen were deliberately avoided in the early screening notice. From the third-and fourth-tier cities, I hope to use the "small town youth" who are more likely to resonate emotionally to carry out the first round of word-of-mouth fermentation.

Nezha takes the opposite strategy, with the early screening starting from first-and second-tier cities, and then gradually expanding downward to third-and fourth-tier cities. In terms of adult-oriented animated films, audiences in cities such as Beijing, Guangzhou and Shenzhen are relatively receptive.

Among the film types of box office in the whole year, the total box office of animated films, led by Nezha, was 6.979 billion, accounting for 18.91% of the whole year, ranking second in the box office list of genre films. The feature film won the championship with 9.278 billion yuan, the comedy film came in third with 5.801 billion yuan, and the science fiction film came in fourth with 4.771 billion yuan.

Guangdong Province, Jiangsu Province and Zhejiang Province rank among the top three in the TOP10 box office output list of provinces. In the national cinema box office rankings, WANDA CINEMAS, Guangdong Dadi and Shanghai jointly ranked the first, second and third place from high to low. Since relevant statistics were available in 2014, Wukesong Store of Beijing Yaolai Jackie Chan International Studios has won the national box office ranking for six consecutive years.

In 2019, the two-way maturity of market and audience made China film market create many records. What is more gratifying is that more and more domestic films go abroad and spread oriental culture on a global scale.In 2020, what "peaks" will China film market climb bravely? Time will tell.

　　China, Oct. 13 (Xinhua) According to the newspaper newspaper quoted by Russian New Network, the legislative council elections in various regions of Russia ended with the unprecedented failure of Russian communist party. The Communist Party of Russia lost two seats in five regional legislative assemblies. The Russian Communist Party believes that the Russian authorities have begun to implement the policy of excluding communist party people from legitimate politics.

　　On Sunday, elections for regional legislative assemblies were held in Sakhalin, Irkutsk, Kemerovo, Transbaikal Territory and Chechen Republic. In five regional elections, the "United Russia" party won a total victory, while communist party, Russia, unexpectedly suffered a crushing defeat. The All-Russia Party won the overwhelming majority of seats in the legislative assemblies of the above five federal entities, while the Russian Communist Party did not even get a seat in Kemerovo and the Chechen Republic.

　　In these two federal entities, the United Russia Party won more than 80% of the votes. Then, unlike the Duma election, the Russian Communist Party failed to keep the second place, but was robbed of the runner-up position by the "Just Russia" party. The final result was that the Russian Communist Party suffered "Waterloo" in Kemerovo and the Chechen Republic-not even a seat was saved. However, the turnout rate in other regional legislative assembly elections is 13% (Outer Baikal Territory) to 22% (Sakhalin State).

　　The defeat of the Russian Communist Party is unprecedented. Within the Russian Communist Party, Vadim Solovev, a member of the Duma, said that he was not surprised at this result. According to the newspaper, Solovev said, "Everything is moving in the opposite direction." The scandal in Kemerovo’s pre-election campaign was so extreme that zyuganov, leader of the Russian Communist Party, had to seek the support of Russian Prime Minister and Chairman of the United Russia Party last week. According to communist party sources, Putin agreed to call Kemerovo Governor Tuleyev. Within the Russian Communist Party, Tuleyev is regarded as the main person in charge of the election campaign. But Putin’s phone call didn’t play any role.

　　The Russian Communist Party believes that the results of the legislative elections in Kemerovo and Chechen Republic are the "stain" of the party. Solovev believes that "these signals are not only sent to the Russian Communist Party, but also to the whole society: the election committee and the regional government are completely obedient to the United Russia Party, and the election has become a farce. The opposition was completely wiped out, leaving only the Russian Communist Party. However, if this kind of election is held again, things like local elections in Chechnya and Kemerovo will probably happen again in Russia. " He also said that "the Russian authorities imitated the Soviet Union and communist party to establish a vertical leadership and management system".

　　He promised, "but we will still struggle, even though we are far from the authorities, just like a 12-year-old boy compared with the special forces." So this is a life-and-death struggle. " (thin horse)

　　Relevant information United Russia Party and Just Russia Party

　　United Russia party

　　The United Russia Party was founded on December 1, 2001, which was formed by the merger of the United Party, the Motherland Movement and the All-Russia Movement. In December 2003, the United Russia Party won a great victory in the fourth State Duma election and became the core force influencing the parliament. As of May 2006, the United Russia Party has a total of 1.044 million people in party member, and has more than 2,000 members in the national legislative bodies at all levels, including 246 members of the State Duma, 87 members of the Federal Council (the upper house of parliament), more than 40 party member as the chief executive of the federal entity, and more than 500 party member as the leaders of municipal institutions. Therefore, the United Russia Party is also known as the "political party".

　　The United Russia Party supports the principles and policies of Russian President Vladimir Putin, and economically advocates the combination of civilized market economy and social justice. Economic reform and development must be aimed at improving people’s material living standards. Politically, it advocates combining a strong country with respect for civil liberties and human rights, reforming the way of state governance, improving the efficiency of government work, and gradually realizing the transformation of state functions from operators to regulators.

　　In May 2008, Putin became the chairman of the United Russia Party after leaving the presidency.

　　Just Russia party

　　The Just Russia Party was founded in October 2006. It was originally formed by the merger of three center-left parties: the Russian Life Party, the Retirees Party and the Motherland Party. The full name is "Just Russia: Motherland/Retirees/Life". In April 2007, the Russian People’s Party merged into the Just Russia Party, which further enhanced the influence of the Just Russia Party. The current leader of the party is mironov, former leader of the Russian Life Party and chairman of the Russian Federation Council.

　　The purpose of the just Russia party is to promote the solution of many social problems in Russia.

　　Some analysts believe that Medvedev and Putin have been considering establishing a "two-party system" political model, and they will be responsible for promoting "just Russia" and "unified Russia" to play new roles in the future political arena.

Editor: Li Xingcun

　　The 19th National Congress of the Communist Party of China will be held in Beijing on October 18, 2017. The 19th National Congress of the Communist Party of China is an important meeting held under the new situation that our party has entered the decisive stage of building a moderately prosperous society in an all-round way, has entered a critical period of comprehensively deepening reform, has taken solid steps in comprehensively governing the country according to law, and has made significant progress in comprehensively and strictly governing the party.

　　At present, all 40 electoral units across the country have completed the election of representatives to the 19th National Congress of the Communist Party of China. A representative is a flag, and the representatives of the 19th National Congress of the Communist Party of China shoulder the great trust and expectations of the people. How will they perform their duties in a spiritual manner? How can they look forward to the next five years? From now on, CCTV will launch a large-scale column reporting "The Representatives of the 19th National Congress of the Communist Party of China Say". Let us approach the representatives of the 19th National Congress of the Communist Party of China and listen to their stories.

　　“一级警士长是武警士兵最高警衔，和将军一样稀有。”涂颜淼，作为福建消防史上首位“兵王”，凭着坚定的信念和顽强的毅力，在平凡的岗位上做出了不平凡的业绩。先后荣立个人一等功1次，二等功2次，三等功6次，省级以上表彰7次。2008年被评为“全国公安系统抗震救灾先进个人”；2008年被福建省评为“抗震救灾功臣”；2009年荣获省“第二届我最喜爱的十大人民警察”“特级优秀人民警察”“青年五四奖章”；2016年当选为中国共产党福州市第十一次代表大会代表。2017年6月当选为福建省出席党的十九次全国代表大会代表。

　　勤学苦练锻造“铁血精兵”

　　从农家子弟，到铁军兵王，很多人经常问涂颜淼一个问题“你是怎么当上这个兵王的”。他朴实地说：“其实他26年来就做了一件事，就是当年他在第一次出警时，坐在消防车里许下的誓言，努力做一个‘当骨干、懂技术、能救人、会灭火’的过硬消防兵。”扎根基层消防中队26年的9000余个日夜里，涂颜淼一刻也没有放松对自己的要求。别人练一遍他就练十遍，从比武状元到状元教练，涂颜淼参加了福建省消防部队几乎所有的大比武、大汇报、大演习。作为队员，98年参加全省比赛荣获团体第一，99年荣获特勤比武第二。作为教练，07年全省比武团体第一，09年“铁人五项”比武团体第二、16年全省大比武团体冠军……凭借一身过硬的业务技能和丰富经验，一次次在各类业务技能比武考核中摘金夺银，成了消防特勤队伍中的“超级战士”“王牌教头”。

　　随着消防部队灭火抢险救援车辆器材装备不断向“高精尖”发展，倒逼着消防战士综合能力的提升。入伍之初，只有初中毕业的涂颜淼，在消防车辆装备学习和应用上面临很大的压力，但他有一颗永不服输、热爱学习钻研的心。经过日积月累的虚心学习、废寝忘食的刻苦钻研，让他对各类车辆装备和抢险救援器材的“五脏六腑”了如指掌，并在使用中不断革新创造。为提高器材装备一次性向火场的运送量，他把黄河牌厢式移动抢险救援车进行改装，原本只能摆放12具空气呼吸器的抢险车经改装后可摆放空气呼吸器28具、备用气瓶40个，以及发电机、抢险器材等多类型装备，成了重要的器材输送装备车。为了保证电台在火场中能够及时充电，他发明了“逆变器”，让24V电压转变为220V，让电台能及时充电，保证火场的通信联络。作为一名特种车辆驾驶员与操作手，25年行车安全无事故，能熟练驾驶和操作各类灭火消防车、专勤消防车、后援消防车和举高消防车，熟练操作使用消防部队任何器材装备。26年来，先后三次被评为“十佳士官”、被团省委评为“新长征突击手”、被公安部评为“公安现役部队优秀士官人才”二等奖，涂颜淼成了官兵们眼中的红门“爱迪生”、车辆装备“行家里手”。

　　给他一只长臂，他就能降伏火魔；给他一架云梯，他就能救民于水火。26年来，涂颜淼参加各种灭火、抢险、社会救助3000余次，救助遇险遇难群众数百人。谱写了赴汤蹈火、竭诚奉献的消防卫士之歌，锻造了“生命守护者”的英雄形象。曾有领导这样评价他：“如果把消防特勤比作消防部队的一把利剑，那么他就是这把利剑的剑刃！”

　　2008年“5·12”汶川特大地震发生后，涂颜淼在他的女儿持续发高烧39度时，匆匆将女儿送去医院交给妻子后，在第一时间找到领导要求参战，在连续行军15个小时未合眼的情况下，5月14日14时队伍到达青川县城，在余震随时可能发生、倾斜的楼房随时可能坍塌的情况下，连续奋战68个小时救出一名妇女。短短的7天里，涂颜淼共参与各类抢险救援39起，救出被困群众17名，其中生还2名，抢救和疏散各类物资上千万元，并随部队铺设光缆10000余米，帮助青川县恢复了与外界的通信联系。

　　2015年4月6日，漳州古雷石化项目发生爆炸事故。涂颜淼主动请缨，赶赴漳州市古雷开发区腾龙芳烃有限公司爆炸现场。浑身湿透、黑眼圈、声音沙哑的涂颜淼在纷飞的泡沫和雨水中带领战友从水池内抽水，保障609号罐体灭火所需8条干线的用水量。直到4月9日上午10时许，罐体温度明显下降，明火浓烟不再冒出，供水组的四台大功率水罐车才停止了“咆哮”。在战斗期间，在火灾现场有爆炸危险的情况下，根据指挥部命令，涂颜淼舍生忘死深入火场，将第一次撤离时落下的消防车开出至安全区域。在这场史无前例、艰苦卓绝、险象环生的战斗中，他始终不畏艰险，连续作战，坚守一线历时近50多个小时，与战友一道成功扑灭大火，最大限度地保护群众生命财产安全。

　　2017年7月1日，涂颜淼再一次站在了鲜艳的党旗前，庄严地举起右手，作为领誓人，带领全市消防部队新党员进行入党宣誓：“我志愿加入中国共产党……”铿锵有力的誓言深深感染了在场每一名官兵，他是这样说的、也是这样做的，痴心不改、百折不回。

　　回首26年的从军生涯，涂颜淼也有过困惑和迷茫，也想过放弃。2001年，他已经成长为一名班长、驾驶员、特种车驾驶员、训练标兵和带兵骨干。生活上，他结了婚、有了孩子，久而久之妻子也会有一些抱怨和唠叨。每当听到妻子的这些话，他心里萌生了退伍的想法，但每次想起百姓需要他们冲锋陷阵的时候，就打消了离开部队的念想，当时他就带着妻子和女儿到部队转一转、看一看，让她们感受他在部队的训练和生活，和妻子商量着说：“我已经深深地爱上了这份职业，你就让我继续留在部队里吧！既然你选择了做军嫂这条路，那你就跟着我一起吃苦受累吧。”就这样，家人慢慢地理解、认同了他。

　　有人说：“涂颜淼，当兵当到你这份上，值了，够了，可以歇歇了”可是当他亲身感受到消防部队这二十六年来的发展成果，感受到人民群众越来越离不开这支以拯救生命为使命的队伍，想到组织和部队的培养、党和人民的重托，涂颜淼就告诉自己：“不能停，还要努力，还有那么多新装备新技术要学、还要坚守在战斗的一线，要把自己积累的宝贵经验和技能传授给新战友。”26年来他带出了一茬又一茬新兵、培养了一批又一批班长、带出了一个又一个徒弟，现如今，他们都成长为消防队伍中独当一面的精兵强将。他因此被战士们亲切地称为——“兵王淼叔”。（张子亚）

Description:

Do you still remember the Bao Beier wedding at that time, which was a sensational event? At this romantic and festive moment, we witnessed a remarkable scene: Jia Ling protected Ada with his own body, which was moving and made people deeply admire sincere friendship and brave behavior. Time flies, let’s look back at this touching moment again, which can’t help but make people feel deeply moved.

# # Text:

Once upon a time, the sky was filled with the festive atmosphere of weddings, and everyone was looking forward to witnessing the wonderful moment of Bao Beier and Ada, a happy couple. However, at that moment, Jia Ling’s great friendship made the whole wedding even more unforgettable.

Jia Ling, an ordinary and extraordinary girl, has known Ada for many years and has always been friends with each other. There is no gorgeous performance between them, no hypocrisy, only sincere feelings. Because of this, when Ada was in trouble, Jia Ling stepped forward without hesitation.

At the climax of the wedding, a sudden safety accident threw the whole scene into chaos. As the focus of attention, Ada has become the target of criminals. In the atmosphere of panic, Jia Ling did not hesitate to protect Ada with his body, just like a fearless guardian angel.

The scene at that time was unbelievable! Jia Ling stood up and protected Ada tightly. Her eyes revealed firmness and courage, as if to use her body to block all risks for Ada. This scene of heroic behavior at the wedding deeply touched the heartstrings of every witness.

This friendship is not only a tacit understanding between two people, but also a selfless dedication. Jia Ling’s practice not only shows her deep feelings for Ada, but also best explains her friendship. She didn’t consider her own safety, just to protect her beloved friend. This sincerity and selflessness make people feel admired and moved.

Time flies, we look back on this moment, not only to miss that warm time, but also to commemorate the great friendship shown by Jia Ling. Such friendship, like a bright light, guides us to persevere and move forward bravely in adversity.

It is this spirit that makes us believe that there is still sincere friendship in the world. They are like bright stars, flashing in the dark, bringing us hope and courage. Jia Ling’s behavior proves to us that no matter where we are, friendship can resolve difficulties and smooth the ups and downs. When we face setbacks and dangers, we can believe that there will always be someone like Jia Ling who will stand behind us without hesitation and give us the firmest protection.

Looking back at this touching story of Bao Beier’s wedding, we once again deeply realized the power of friendship. Jia Ling’s act of guarding Ada with her own body not only makes us sigh her courage and great love, but also awakens our deep desire for friendship and care.

Let’s remember this friendship together and understand and pass it on with our heart. Perhaps in our ordinary life, we also need such courage and care to protect those friends who have experienced the storm with us. Because as long as there is sincere friendship, we can face the challenges in the future without fear.

May this touching story live in our memory forever, and may the friendship between Jia Ling and Ada become stronger and stronger. Let’s pay tribute to this sincere friendship and make the world full of more power of truth, goodness and beauty!

The above is the headline tweet I created for you about Jia Ling protecting Ada with her body at Bao Beier wedding. Thank you for reading!

Editor in charge:

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The front face design of BMW i4 adopts a closed kidney grille, which not only embodies the family characteristics of BMW, but also enhances the aerodynamic performance of the vehicle. At the same time, the long and narrow headlight group is integrated with the grille, which makes the whole front face look sharper and more dynamic. Overall style, the BMW i4 adopts a streamlined body design, and the low body posture with elegant curves not only shows the sense of fashion, but also improves the aerodynamic performance of the vehicle. In addition, the rear part of the car adopts a relatively simple design language, and the long and narrow taillights echo the headlights of the car, making the whole car look more harmonious and unified.

The body size of BMW i4 is 4785*1852*1455mm, the wheelbase is 2856mm, the front tread is 1601mm and the rear tread is 1630mm, which provides a spacious interior space for the vehicle. The side lines of the car are smooth and dynamic, and the front face is designed with a closed kidney grille, which is very fashionable with slender LED headlights. Tyre size is the front 245/45 R18 and the rear 255/45 R18, and it is matched with an 18-inch aluminum alloy rim, which is sporty and dynamic in style.

The interior design of BMW i4 inherits BMW’s consistent sense of luxury and technology, and the interior space layout is reasonable, creating a spacious and comfortable driving environment. The steering wheel is wrapped in leather, which provides a good grip and support, supports manual adjustment up and down and back and forth, and is convenient for drivers to find the best driving position. The central control screen adopts a 14.9-inch touch screen, which integrates the control functions of multimedia system, navigation, telephone and air conditioning, and supports voice recognition control, which enhances the convenience of operation. The seats are made of various materials, including imitation leather, genuine leather or leather /Alcantara mix and match. The main and co-pilot seats have multiple adjustment functions, including front and rear adjustment, backrest adjustment, height adjustment (4-way), leg rest adjustment and lumbar support (4-way), and have heating function to provide a comfortable riding experience. The car is also equipped with multiple USB and Type-C interfaces to facilitate charging, and the front seats are also equipped with wireless charging function, which provides a convenient charging solution for modern mobile devices.

BMW i4 is equipped with an excellent motor with a maximum power of 210 kW and a maximum torque of 400 Nm, which provides drivers with a strong power output and a smooth driving experience.

The owner of car home said that the configuration parameters of Series I’s 3, 5 and X3 are almost the same, only the shell has been changed, and I want to buy the I4 for the sake of personality. Of course, it is still imported, so there is no need to do such a thing as buying it home and deducting the label. The big nostrils are not mediocre at first glance. When I drive out, everyone guesses at 600,000. I’m sorry.