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Focusing on Drug Targets： ＂Fighting poison with poison＂ —— The latest research progress of oncolytic virus

Since the 19th century, virus therapy for cancer has been studied. However, due to technical barriers and safety problems in genetic engineering, great progress has not been made until the last 20 years. At present, viralvectors for gene therapy and oncolytic viruses (OVs) are the main methods used by viruses as tumor therapy. The main difference between gene therapy virus vector and OVs is that the virus used in gene therapy virus vector is a non-replicating virus, while the vector used in OVs is a virus with replication ability.

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OVs refers to a kind of viruses that can selectively infect and kill tumor cells without damaging normal cells, and they often have good tumor lysis and targeting. OVs can replicate in the host cell after infecting tumor cells, and the released progeny viruses can continue to infect surrounding tumor cells, at the same time activate local or systemic anti-tumor immune effects, change tumor microenvironment and further improve anti-tumor effects. Natural oncolytic virus has some limitations, such as inconsistent safety or weak ability to stimulate the body to produce tumor immunity. In order to overcome the above shortcomings, oncolytic virus vector came into being: it not only retains the ability of oncolytic virus to kill tumor cells, but also enhances its efficacy of activating immune response after genetic modification.

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From non-gene editing type to gene editing type, OVs contains many kinds and characteristics. According to the different nucleotide types of virus genome, OVs vectors can be divided into DNA virus vectors and RNA virus vectors. Among them, the main DNA viruses are herpes simplex virus (HSV), adenovirus (AdV), vaccinia virus (VV) and H1(parvovirus H1. RNA viruses are mainly reovirus (RV), coxsackie virus (CV), poliovirus (PV), measles virus (MV), NDV and vesicular stomatitis virus (VSV).

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The latest research progress

1. At present, five products have been approved for listing in the world, and it is predicted that they will reach the market of over 10 billion dollars in the future.

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2. According to the data of Toubao Research Institute, the market size of oncolytic drugs in China will continue to grow at a compound annual growth rate of 16.2%, and it is expected to rise to 1.43 billion yuan by 2024.

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3. According to the number of research targets, they are IL-12, GM-CSF, PD1, IL-15, PDL1, CD, CD19, CTLA4, NIS, etc.

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4. In the research enterprises, among them, there are many researches and developments on oncolytic viruses, such as Icell Kealex Therapeutics(10), Cell Genesys(7), Virogen Biotechnology (6), PsiOxusTherapeutics(5), Transgene(5) and Jennerex(4). In addition, domestic enterprises such as Innomicro, Synbiotics, Shanghai Medicine, Ruotai Medicine, Kangwanda Medicine, Saibainuo, Lepu Bio, Tasly, and Funuojian are also deployed in this field.

5. Statistics of drugs currently in clinical research stage are as follows:

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two

Introduction of key drugs

Among the five oncolytic viruses approved worldwide, including picornavirus Rigvir, which is approved for the treatment of melanoma in Latvia; Secondly, today’s reborn (recombinant human P53 adenovirus injection) and recombinant human adenovirus type 5, which were approved in 2004 and 2005 respectively, were approved for the treatment of solid tumors such as hepatocellular carcinoma, nasopharyngeal carcinoma and pancreatic cancer. In 2015, the United States and Europe approved the engineered herpes simplex virus (HSV-1) of talimogene laherparepvec(T-VEC) for the treatment of unresectable metastatic melanoma. Finally, in 2021, Japan approved the improved herpes simplex virus teserpaturev for the treatment of brain cancers such as glioblastoma. The statistic of some drugs in that lead stage of clinical development are as follows:

1、CG0070

CG0070 is a genetically modified adenovirus type 5 (Ad5), which contains cancer selective promoter E2F-1 and immune cell stimulating factor GM-CSF gene, and selectively replicates and lyses tumor cells in Rb-deficient tumor cells. The rupture of cancer cells will release tumor-derived antigen and GM-CSF expressed with the virus, thus stimulating systemic anti-tumor immune response. CG0070 was introduced by Lepu Bio from CG Oncology in the United States, and obtained its product development rights and global supply rights in China; Except China, the rights and interests in Japan, South Korea, China, Taiwan Province and other Asian countries were acquired by Kissei Pharmaceutical.

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2、Pelareorep

Pelareorep(AN1004) is a non-pathogenic reovirus introduced by Oncologics Biotechnology by Arnold Pharmaceuticals. It can overcome the neutralizing antibody, selectively infect and destroy tumor cells by activating the body’s own immune system, and is used to treat various solid tumors and hematological malignancies. Pelareorep is a rapidly developed oncolytic virus product that can be administered by intravenous injection in the world. The second phase clinical trial of Pelareorep in the treatment of metastatic breast cancer found that the overall survival rate of patients with ER+PR+/HER2- breast cancer was doubled (21.8 months vs. 10.8 months). In its global phase II clinical trial (BERIL-1) for the treatment of head and neck squamous cell carcinoma (HNSCC), the median survival time of patients was as high as 10.4 months. In March, 2022, Oncologics Biotechnology announced that it had completed the safety assessment of three patients in the metastatic colorectal cancer (mCRC) cohort of the oncolytic virus Pelareorep phase 1/2 GOBLET study.

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3、pexastimogene devacirepvec

Pexastimogen devacirepvec (JX-594) is a genetically engineered vaccinia virus introduced from abroad by Lee’s Pharmaceutical Factory. Its TK gene is mutated, and human GM-CSF gene is inserted to enhance the anti-tumor immune response. The advantages of using vaccinia virus include the stability of intravenous infusion, strong cytotoxicity and the safety of classical live vaccine. Previously, the drug had poor clinical performance in phase III of hepatocellular carcinoma, and the efficacy of the drug in combination with cemiplimab in the treatment of renal cell carcinoma is currently being evaluated.

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4. Naomi Loki

Loki (GL-ONC1, Olvi-Vec) was developed by Genelux Company, and Hengyi Bio owns its development rights in Chinese mainland. It is an oncolytic vaccinia virus. Three expression cassettes encoding β-galactosidase, β-glucuronidase and renin luciferase/green fluorescence (RLuc-GFP) fusion proteins are used to replace virus TK, hemagglutinin and F145L genes respectively. A phase I clinical trial of GL-ONC1 in patients with head and neck cancer showed that intravenous injection of GL-ONC1 combined with standard chemotherapy could improve the overall survival rate. This study also proved the safety of the virus.

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5、OH2

OH2(BS001) is the first candidate drug for oncolytic virus in the world, which is independently developed by Binhui Ib/II-tech, and has chosen HSV2-2 as the carrier and entered clinical trials. Clinical data show that the objective remission rate (ORR), disease control rate (DCR) and one-year survival rate (OS) of BS001 are 30%, 50% and 50%, respectively. In addition, the latest clinical data in the treatment of colorectal cancer show that the objective remission rate of BS001 injection in the treatment of colorectal cancer patients has exceeded 10%. The objective remission rate of BS001 injection combined with PD-1 monoclonal antibody was 18.2%.

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prospect

In recent years, with the development of genetic engineering technology, people have a deeper understanding of the function and structure of virus genes. Optimizing the design and operation of virus genome to produce non-pathogenic viruses has become the research direction of oncolytic viruses, which has greatly promoted the progress of oncolytic virus therapy. Combined treatment of oncolytic virus with chemotherapy or immunotherapy drugs, or even combined application of multiple oncolytic virus drugs, may control tumor progression or cure tumor more effectively, and provide potential clinical treatment options for tumor patients. We believe that with the deepening of oncolytic virus research, oncolytic virus therapy will play a wider and deeper role in treating human diseases.

references

Yang Hao, Zhang Shaogeng, Yang Penghui. Immunological mechanism and clinical research progress of oncolytic virus [J/OL]. Progress in biochemistry and biophysics: 1-16.

[2] Liu P, Wang Y, Wang Y, et al. Effects of oncolytic viruses andviral vectors on immunity in glioblastoma[J]. Gene therapy, 2020: 1-12.

[3] Kaufman H L, Kohlhapp F J, Zloza A. Oncolytic viruses: a newclass of immunotherapy drugs[J]. Nature reviews Drug discovery, 2015, 14(9):642-662.

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Experts explain how to understand China’s economy turning to high-quality development.

　　If you open the column,

　　The 19th National Congress of the Communist Party of China put forward that China’s economy has changed from a high-speed growth stage to a high-quality development stage, and it is in the key period of changing the development mode, optimizing the economic structure and transforming the growth momentum. Building a modern economic system is an urgent requirement for crossing the barrier and a strategic goal for China’s development.

　　In order to better understand and implement the spirit of the 19th National Congress, this edition will launch a series of reports on "Focusing on the 19th National Congress Report and Turning to the Stage of High-quality Development", and invite experts to discuss relevant issues, so please pay attention.

　　The just-concluded 19th National Congress of the Communist Party of China made a historic conclusion that "China’s economy has shifted from a high-speed growth stage to a high-quality development stage".

　　Why did China’s economy turn to a high-quality development stage? Compared with the high-speed growth stage, what new changes and trends will be presented in the new stage? In the process of turning to the stage of high-quality development, how can we seize the opportunity, tackle key problems, win the victory and build a well-off society in an all-round way, and advance towards the goal of "two hundred years"?

　　How to understand "turning to high-quality development"

　　Emphasize quality rather than speed, and development rather than growth.

　　From the high-speed growth stage to the high-quality development stage, China’s economy has once again made a clear path choice.

　　— — Change the development mode, realize intensive economic growth and improve total factor productivity.

　　“‘ Turn to high-quality development ’ The essential meaning of this assertion is that China’s economy has changed from extensive high-speed growth mainly relying on increasing the consumption of material resources to intensive growth mainly relying on technological progress, improving management and improving the quality of workers. " According to Zheng Xinli, executive vice president of China International Economic Exchange Center, it is an epoch-making change for the economy to shift from a high-speed growth stage to a high-quality development stage.

　　"China’s economic development is no longer entangled in whether the economic growth rate is faster or slower. Instead, it is to improve the total factor productivity and promote the quality change, efficiency change and power change of economic development." Zheng Xinli stressed.

　　In 2016, China’s "Top 100 Counties" created more than 11% of the country’s GDP； with 2% of the country’s land area and 6% of the population; The per capita disposable income of urban residents is 39,165 yuan, which is 16.5% higher than the national average. The per capita total retail sales of social consumer goods is 31,000 yuan, which is 29% higher than the national average. Throughout the development of "Top 100 Counties", all of them have changed from the extensive development mode driven by original resources and investment to the intensive development mode driven by innovation, which ushered in a brand-new development opportunity.

　　“‘ High-quality development stage ’ In terms of industrial structure, it has changed from resource-intensive and labor-intensive industries to technology-intensive and knowledge-intensive industries. In terms of product structure, from low-tech products with low added value to high-tech products with high added value; In terms of economic benefits, it has changed from high cost and low benefit to low cost and high benefit; In the ecological environment, it has changed from high emission and pollution to circular economy and environment-friendly economy. In the end, it will be reflected in the continuous strengthening of the country’s economic strength and the rapid increase of residents’ income. " Zheng Xinli said.

　　— — Enrich the connotation of development, aim at fuller and more balanced development, and enhance people’s sense of gain.

　　From the result-oriented perspective, the "high-quality development stage" highlights the people’s sense of gain. Gao Peiyong, director of the Economic Research Institute of China Academy of Social Sciences, pointed out that "high speed" refers to quantity or scale, which is often the goal of the primary stage of economic development, and is used to mark "fast and unhappy"; "High quality" is the goal that will only be achieved after the economic development reaches a certain level. Emphasizing quality and efficiency is the answer to "good".

　　"Growth only refers to the expansion of the economic aggregate; The connotation of development is richer, in order to meet the people’s growing needs for a better life. " Gao Peiyong said that China has solved the problem of food and clothing for more than one billion people, achieved a well-off society on the whole, and will soon build a well-off society in an all-round way. The people have not only put forward higher requirements for material and cultural life, but also increasingly demanded democracy, the rule of law, fairness, justice, security and the environment. Therefore, economic development should change from simply pursuing total expansion to meeting people’s higher standards and more diversified needs.

　　Why do you propose "turning to high-quality development" now?

　　Facing the contradictions in the new era and breaking through the bottleneck of development

　　Historically, economic development is repeating "prosperity — Recession — Recovery — At the same time, we should take the progress of science and technology, human resources and other factors as new kinetic energy, solve the deep-seated contradictions that restrict economic development, and realize the overall upward trend. "From the high-speed growth stage to the high-quality development stage" is a necessary choice and urgent task for us to face the main contradiction in the new era and adapt to the new economic normal.

　　— — The main contradiction at this stage requires us to give up speed preference and attach importance to development quality.

　　Gao Peiyong believes that the important conclusion of "changing from a high-speed growth stage to a high-quality development stage" is consistent with the fact that the main contradiction in our society has changed into the contradiction between the people’s growing need for a better life and the unbalanced development.

　　At present, the total consumption of energy and raw materials in China is too large, and the energy consumption per unit GDP is too high. "The growth of extensive economic has put increasing pressure on resources and the environment, and such a growth model is difficult to sustain." Zheng Xinli pointed out.

　　In recent years, large areas of haze weather have appeared in North China and East China, and the incidence of some diseases related to environmental pollution has increased. "If development needs to pay the price of people’s health, it goes against the original intention of development. The 19 th National Congress of the Communist Party of China proposed to turn to a high-quality development stage, which is to respond to the concerns of the people and face the deep-seated contradictions of economic development. " Zheng Xinli said.

　　"China’s economy has maintained high growth for decades, creating a lot of social wealth, and Chinese has gained great benefits from the reform and opening up. However, due to the imperfect market economic system and the imperfect distribution system, some social and economic problems worthy of attention have emerged, such as the urban-rural gap, the regional gap, and the industry gap. The people’s demands for coordinated development and balanced development have been continuously improved. " Wang Yukai, a member of the National Informatization Expert Advisory Committee, believes that we must pay attention to the transformation of major social contradictions, change the mode of production, adjust the pattern of interests, increase the cohesion and centripetal force of the nation, and stimulate the creativity and development vitality of the whole society, so as to achieve higher quality, more efficient, fairer and more sustainable development.

　　— — Shifting from a high-speed growth stage to a high-quality development stage is also a realistic choice to actively adapt to the new economic normal and break through the bottleneck of development.

　　"We must adapt to the new normal of economic growth and shift gears and maintain a strategically normal mentality. We must downplay the speed ‘ Obsession ’ Strengthen quality awareness, optimize factor input, and promote coordination in all aspects of modernization. " Bai Jingming, vice president of China Academy of Fiscal Science, believes that relying on advanced elements such as talents, technology, knowledge and information, and driven by innovation, we can eliminate the adverse effects of globalization dividend and China’s declining demographic dividend, break through the bottleneck constraints of resources, energy and environment, and realize the transformation of old and new kinetic energy as soon as possible.

　　How to "turn to high-quality development"

　　Having won the first battle, we should persist in changing the development mode, optimizing the economic structure and transforming the growth momentum in the future.

　　"From high-speed growth to high-quality development, we are confident and experienced." Bai Jingming pointed out that at present, the traditional industries are full of vitality, the new industries have a strong momentum, and the new economy is accelerating. China’s economic restructuring is gradually coming out of the painful period and entering the harvest period. "In the first three quarters of 2016, the income tax of industrial enterprises was 584.3 billion yuan, an increase of only 0.6%; In the same period of this year, the income tax of industrial enterprises increased by 21.3% year-on-year, which was particularly obvious. There are factors such as a low base last year and rising prices this year, but more importantly, enterprises have taken the initiative to adjust their structure and the added value of high-tech industries has increased substantially. "

　　Since the 18th National Congress of the Communist Party of China, innovation and development have released strong kinetic energy and created one "China Miracle" after another; Coordinate development to make up for shortcomings and make development more stable; Green development is firmly advanced, and man and nature are more harmonious; Open development will achieve mutual benefit and win-win results, and the development world will be broader; Sharing development enhances people’s well-being, and social fairness and justice are more prominent … … Practice has fully proved that we have won the first battle and stood on the platform of "high quality development" in the new era.

　　However, we still face many challenges from high-speed growth to high-quality development.

　　For example, there are still a considerable amount of capital, land and labor resources, which are deposited in industries with serious excess capacity and high pollution, which has dragged down economic transformation and efficiency improvement. Through supply-side structural reform, these essential resources should be gradually transferred and injected into emerging and green industries.

　　Another example is that decentralization has achieved remarkable results, and enterprises have gone into battle lightly, but the interconnection of information systems between various departments and governments at all levels needs to be accelerated. "A national unified government service platform should be formed so that enterprises and the masses can feel more about ‘ Streamline administration, delegate power, strengthen regulation and improve services ’ The effectiveness of the reform, in addition to the disadvantages of annoyance, the implementation of fair policies, and the opening of the door to convenience. " Wang Yukai said.

　　For another example, green development still has a long way to go. Judging from the cases exposed by the Central Environmental Protection Inspector Group in the past two years, some places still have stubborn diseases and bad habits of sacrificing green mountains and green hills for Jinshan Yinshan.

　　The stage of high-quality development is irreversible, and the task of high-quality development cannot wait, so we need to roll up our sleeves and work hard.

　　The report of the 19th National Congress of the Communist Party of China put forward six strategic measures, including deepening supply-side structural reform to promote the transformation and upgrading of industrial structure and product structure; Accelerate the construction of an innovative country, and promote the improvement of quality and efficiency with independent innovation technology; Implement rural revitalization strategy and regional coordinated development strategy to solve the problem of unbalanced and insufficient economic development and release new kinetic energy of economic development; Accelerate the improvement of the socialist market economic system, establish institutional mechanisms conducive to improving the quality of economic development and improving the ecological environment, and enhance the vitality of economic development; Promote the formation of a new pattern of comprehensive opening up and make better use of global markets and resources.

　　"In the future, we should still persist in transforming the development mode, optimizing the economic structure and transforming the growth momentum." Gao Peiyong pointed out that in the future, economic development will still shift from extensive growth of scale and speed to intensive growth of quality and efficiency, and from incremental capacity expansion to deep adjustment of adjusting stocks and doing both excellent and incremental; From traditional growth point to new growth point. "These tasks are consistent with the economic policy framework formed since the 18th National Congress of the Communist Party of China, that is, the economic policy framework based on the major judgment of the new normal of economic development, guided by the new development concept and with the supply-side structural reform as the main line. Next, in the process of implementing the spirit of the 19 th National Congress of the Communist Party of China, these policies should be continuously deepened, refined and rigidly implemented. " Gao Peiyong said.

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COVID-19, 60-year-old CEO of Pfizer, was positive： he claimed that his symptoms were mild and he had taken his own oral medicine.

　　Pfizer CEO Abel Le data map

　　What kind of treatment plan will the CEO of "the first pharmaceutical factory in the universe" accept after his nucleic acid test is positive?

　　On August 15th, local time, official website of Pfizer (NYSE：PFE) issued a statement saying that CEO Albert Bourla tested positive for COVID-19. In a statement, Albright said that she had been vaccinated with four doses of Pfizer/Bionta COVID-19 vaccine, and she felt good but had mild symptoms. She was being quarantined and following public health precautions. In terms of treatment, I have started taking Paxlovid, the company’s oral medicine for COVID-19.

　　Abel said that he believes that he will recover soon.

　　Who’s Abel?

　　On October 1, 2018, Pfizer announced that the board of directors of the company unanimously elected 56-year-old Pfizer COO Abel as CEO of Pfizer, which took effect on January 1, 2019.

　　According to the official information released by Pfizer China at that time, before becoming COO on January 1, 2018, Abreu led Pfizer’s innovative medical business and established innovative medical emerging market areas. Prior to being appointed as the head of Pfizer’s innovative medical business, Ai Bole became the president of the Vaccine, Oncology and Health Drugs Business Group in January 2014. Under his leadership, the tumor business has tripled in four years, the vaccine business has increased by 50%, and the health medicine business has significantly improved its profitability.

　　In addition, Arbelot also led several key transactions to promote Pfizer’s investment portfolio in the fields of cancer, inflammation and immunity, vaccines and rare diseases, and to create a strong and leading cancer business in the franchise field of breast cancer and prostate cancer through priority investment.

　　The history of Pfizer can be traced back to 1849, and it is headquartered in new york, USA. During its development, the forms of acquisition, merger and sale have gradually developed. As the world’s top pharmaceutical company, Pfizer was once called "the first pharmaceutical company in the universe" in the pharmaceutical industry. Under the leadership of Albrecht, Pfizer has made many changes, such as divesting generic drug business in 2020, which was called "the first year of transformation" by Pfizer in 2021, and the company is transforming into a scientific-based, innovative and patient-oriented biopharmaceutical company.

　　It was also during the period when Albrecht served as CEO that the world experienced the test of COVID-19 epidemic. Pfizer obtained the preventive mRNA COVID-19 vaccine through cooperation with BioNtech, and promoted the use of Paxlovid, a small molecular oral drug in COVID-19, in many markets. These two products also led to the soaring performance of Pfizer. According to the revenue data in 2021, Pfizer ranks second in the world, second only to Johnson & Johnson.

　　In the second quarter, COVID-19’s vaccine and oral medicine contributed 12.6 billion US dollars in revenue.

　　In the statement, Aibole mentioned that he had been vaccinated with COVID-19 vaccine and was taking oral medicine, which was also the driving force for Pfizer’s strong performance.

　　On July 28th, local time, Pfizer released its financial report for the second quarter of 2022, showing that its revenue in the second quarter was US$ 27.7 billion, a year-on-year increase of 47%. In terms of net profit, the revenue in the second quarter was 9.91 billion US dollars, a year-on-year increase of 78%. "In the second quarter, we achieved the largest quarterly sales in history," Pfizer quoted Abel as saying in a press release.

　　Some data of Pfizer’s second quarterly report

　　Behind the growth of revenue in the second quarter, it mainly benefited from the contribution of Paxlovid, a new oral drug, and Comirnaty, an mRNA COVID-19 vaccine. Specifically, COVID-19’s sales of oral drugs were $8.1 billion, and COVID-19’s sales of vaccines were $8.8 billion. Together, they contributed $12.6 billion in revenue, accounting for about 45% of the total revenue in the second quarter.

　　At the end of 2021, the US Food and Drug Administration (FDA) urgently approved Pfizer’s COVID-19 oral drug Paxlovid, which was also the first approved oral COVID-19 drug in the United States. According to the second quarterly report, in the second quarter, the drug was sold in the United States for $4.5 billion, accounting for about 55% of the market sales in the current quarter. According to Pfizer’s first quarterly report this year, the drug contributed $1.47 billion in revenue in the first quarter, with sales in the US market accounting for 69%. Pfizer’s annual sales guideline for the drug remained at $22 billion.

　　Comirnaty is an mRNA COVID-19 vaccine that Pfizer cooperated with Baiou Entai Company. It was first approved for trial in the United States and other countries and regions at the end of 2020. The second quarter financial report showed that the revenue of the vaccine in the United States was $1.1 billion, down by 47%, while it increased by 43% in other international regions. By July 20th, more than 3.6 billion doses of vaccine had been distributed to 180 countries and regions.

　　Pfizer expects the annual revenue range to be $98 billion to $102 billion, which is consistent with previous forecasts.

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Dream! ＂Yesterday’s Miracle＂ was certified by Beatles fans with full marks.

1905 movie network news byProduced by British Voctetto Film Company.Comedy movieIn the national popularity, the film is full of sincere emotions and frequent laughter, creating a relaxed and pleasant atmosphere for watching movies. With the familiar Beatles golden songs and the different sparks between the protagonists, it has aroused extensive discussion among the audience and gained the spontaneity of movie-watching fans."Amway" is called "a dream that can’t be missed" this summer.


　

As a tribute to the Beatles’ fans, the Beatles’ golden melody feelings not only run through the film, but also become the most talked about part of the audience. Some viewers bluntly gained unprecedented satisfaction and happiness during the movie viewing. "Most people still insisted on listening to the whole" Hey Jude "with the subtitles, knowing that there were no eggs." Some viewers were moved to tears by the appearance of "the 78-year-old man by the sea", and they all said that John Lennon was "still handsome with that pair of glasses and long hair." The audience who walked into the cinema with the feeling of recalling youth agreed: "The world without the Beatles is a terrible world. If you like rock music and Beatles, go to see this movie. It’s a wonderful world. "

　

In addition, the audience have praised the elements of music, dreams and love in the film, saying that the purest and most touching part of the film lies in the combination of music and love. "To stick to what you love, music is so persistent." It is worth mentioning that in addition to the Beatles’ golden songs, the film also added the works of "Boss Huang" ed sheeran, which made music lovers shout that they were "addicted enough". In the film, he played "Bole" who discovered the talent of the male host Jack, and witnessed Jack’s fame all the time. His performance was also well received, just as the comments of iQiyi Bubble and Bazaar Entertainment: "Boss Huang’s appearance greatly added points" and "people"

　

The collaboration between Oscar-winning director Danny Bauer and screenwriter richard curtis also amazed the audience. The setting of "The whole world forgets the Beatles" made the audience applaud: "richard curtis writes love stories in a unique way, and a little surreal elements can make them completely wonderful." The Beatles’ memory killing, which was sung by the audience all the time, showed the director’s mastery of the mirror, and the audience praised the songs and jokes just right. "You can hear the laughter of people around you when the songs and stalks of various insect groups appear."

　

"Yesterday’s Miracle" is being shown all over the country, waiting for the miracle to come. It is better to seize the moment and go to the Beatles Music Qimxy with amateur singer Jack!

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Director Ne Zha talks about the sequel： Do it if you can!


1905 movie network news Recently, domestic animated films have accumulated a good reputation in a large-scale nationwide screening, and Douban has risen to 8.7 points. At a premiere, director jiaozi talked about the plan to shoot a sequel: "I will continue to do it if I can return to this book."


"If the film can be returned, we will continue to do it. And I also spent a little thought, adding eggs at the end can arouse the audience’s desire. In terms of investment, the ducks will be put on the shelves. Since the four dragon kings are all together, they will definitely do something. " Jiaozi, the director, said when asked questions at the scene.


At the same time, jiaozi also said that the sequel script is still in the outline stage, and it needs a long time to polish. "If there’s something that I can’t get through myself and don’t think is the best thing, I won’t show it to everyone."


Two years ago, the producer, Light Striped House Film, released a film list, announcing that it would make a domestic animation "Myth Trilogy", and the last two parts were Phoenix, except Ne Zha.

Legend of Deification concept poster


"Phoenix" concept poster


The film Ne Zha will be officially released on July 26th.

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Covid-19 leaked from the lab？ That’ll be the day! Four reasons to see American virus experts

　　"Business Insider" reported on the 2 nd that Jonna Mazet, an epidemiologist at the University of California, Davis, who had trained and cooperated with Wuhan Virus Research Institute, believed that,It is highly unlikely that the spread of Covid-19 originated from a laboratory leak., and listed four reasons.

　　△ "Business Insider" report screenshot

　　Reason 1: The laboratory samples don’t match Covid-19.

　　The article pointed out that after Jonah Mazet’s team sequenced Covid-19, Shi Zhengli, a researcher at Wuhan Virus Research Institute who had worked with her before, immediately went to check the experimental records andThe genetic information of the new coronavirus was compared with other coronaviruses found by the team in bats before, and it was found that they did not match.

　　△ Epidemiologist Joanna Mazet said that her colleagues compared the genome of the new coronavirus with the genetic information of other bats collected by the previous team, and then found that they did not match.

　　At the same time, Mazet and Shi Zhengli also stressed that,Before the outbreak of COVID-19, they had never detected other viruses related to it.

　　△ Mazet said that her colleagues were very sure that this virus had never been identified before the outbreak in COVID-19.

　　Reason 2: The laboratory implements strict safety protocols.

　　Mazette pointed out that some people had questioned the safety of Wuhan Institute of Virology (WIV) of Chinese Academy of Sciences before, but she thought that whether in the laboratory or at the sampling site,The work of researchers in China is beyond reproach.

　　△ Jona Mazet: Shi Zhengli’s work is beyond reproach.

　　She also said that the protection work of laboratory researchers is in place.At the same time, when studying samples, researchers only use inactivated and non-infectious samples.

　　△ Mazette said that when studying samples, researchers only use inactivated and non-infectious samples.

　　Reason 3: Covid-19 is the latest virus that broke out in zoonotic diseases.

　　The report also said that experts pointed out thatThe outbreak of the new type of coronary pneumonia is not due to leakage, but more likely because COVID-19 is the latest disease spreading from animal hosts to humans.

　　△ Experts pointed out that the outbreak of COVID-19 epidemic was not caused by leakage, but more likely because COVID-19 is the latest disease spreading from animal hosts to humans.

　　Reason 4: Ordinary people are more exposed to live viruses than researchers.

　　In addition, Mazet said,Covid-19 is not the fourth reason for leaking from the laboratory, but ordinary people are more exposed to live viruses than researchers.She believes that caves and wild environments where bats are sampled will be more dangerous for ordinary people, because researchers use personal protective equipment (PPE) when collecting samples, but ordinary people may not use it.

　　△ Mazette said: "The caves and wild environments where samples are collected are dangerous places for people, because they may be exposed to viruses that live in animals."

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Chinese and Russian fans wish from a distance： ＂Welcome to Beijing’s blessed land＂ and ＂moved to tears＂

　　The pace of the opening ceremony of Beijing Winter Olympics is getting closer and closer.

　　When athletes from all over the world are actively preparing for the war, their fans are also gearing up and cheering, expressing their enthusiasm for the Beijing Winter Olympics and their blessings to the athletes.

　　Russian flower skaters Camilla Vallier, Anna Sher Bakova and Alexandra Trousseau will compete as women’s singles players. They are affectionately known by China fans as the Russian "Dolls" group.

　　Camilla Vallier, Anna Schell Bakova and Alexandra Trousseau (Source: vision china)

　　Russian "Taowa" Sky MissionThere are countless powders in China

　　Although the three athletes are young, each of them is stunted and dancing on the ice and snow field.

　　Camilla Vallier, who is only 15 years old, has been called "K Bao" by China fans, and has entered the adult competition since October 2021.

　　Camilla Vallier (Source: Russian Tass)

　　She said in an interview: "I feel very happy to participate in the Olympic Games, which may be every athlete’s dream … … I also really want to see the Great Wall in Beijing, which will be very interesting. "

　　Anna Schell Bakova (Source: vision china)

　　Anna Schell Bakova is 17 years old and is called "the golden daughter" by China fans.

　　On January 26th, Shel Bakova exposed the winter Olympic souvenirs given to her by China fans on overseas social media, and wrote: "Thank you very much for the support of China fans and these Olympic souvenirs."

　　Anna Schell Bakova social media screenshot

　　Seventeen-year-old Alexandra Trousseau Eva is called "Sasha" by China fans. She is the first female figure skater to complete the hook jump around, the back outside ice jump around and the back inside ice jump around in an official international competition.

　　Alexandra Trousseau (Source: vision china)

　　Chinese and Russian fans send warm wishes to "Love Bean"

　　When the athletes are fully preparing for the Olympic Games and are about to start their dream trip, the fans of the "Doll" team warmly shouted and cheered them on.

　　Many fans have made refueling placards for their "love beans" and sent their best wishes enthusiastically.

　　A China fan said to Camilla Vallier, "I hope you can feel the enthusiasm of this city, and I will always support you."

　　A Russian fan said to Camilla Vallier: "I hope that the Olympic trip and excellent results will bring you full happiness at the time of triumph."

　　And China fans expressed to Anna Schell Bakova in fluent Russian: "Dear Anna, I wish you good luck and keep moving forward. We believe that our Anna can do it. "

　　A China fan told Anna Schell Bakova: "China is ‘ Qianjin ’ Blessed land, I hope we can witness it together ‘ Qianjin ’ On the podium at the Beijing Winter Olympics. "

　　Chinese and Russian fans shouted from a distance, ice fans interacted and burned the winter Olympics.

　　China fans not only send their blessings to Aidou, but also shout to Russian fans from a distance. A fan said: "We will pass on the cheer to the athletes for you. After the epidemic has passed, I hope you will come to Beijing to have a look."

　　A fan said: "Although we come from different countries, we are all family."

　　After China fans’ refueling videos were released on Russian social media, they were reported by RIA Novosti and Russian newspaper.

　　Russian News Agency official website screenshot: "China ice fans cheer for Russian women’s singles skaters"

　　"Russian newspaper" official website screenshot: "China ice fans cheer for Russian women’s singles skaters"

　　On major social media, Russian netizens responded positively to the blessings of China fans, and ice and snow sports fans from different countries resonated on the same frequency.

　　Anna Pavlova, a user of Russian social media VK, said: "Friends, thank you for your support to the beautiful Camilla!"

　　Irina.bezginova, a social media INS user, said: "Moved to tears! Tears of joy and gratitude, thank you very much!"

　　Czernowitz.city, an INS user, said, "Thank you very much for Anna’s fans in China.Especially girls who speak Russian. I hope our common support will give Anna strength and look forward to her perfect performance."

　　The common love for the "Taowa" group has brought Chinese and Russian netizens closer and closer. Some netizens said that they would cheer for "Aidou" together and support them as one:

　　VK netizen Rezeda Ratbova said: "China’s fans are amazing,Camilla must be very happy to know that someone is waiting for her, loving her and trusting her.Let’s work together for our‘idol’Come on, I wish her all her wishes come true, everything goes well and success will come soon!"

　　INS netizen taisia_lyubimova said: "Thank you, dear China fans, love you! With your support, we will feel at ease.We stand together is strength!"

　　Russian fans also sent their blessings to the athletes and volunteers of the China Winter Olympics.

　　"Among the athletes in China, I would like to mention Jin Boyang, a male single skater, who will also take part in the Beijing Winter Olympics. I wish him all the best, complete the jump well and successfully complete the jump around. "

　　"I wish China pair skaters Sui Wenjing and Han Cong a well-deserved championship in the Winter Olympics."

　　"Hello, volunteers of Beijing Winter Olympics. Enjoy the wonderful time in the upcoming sports event. "

　　The world is but a little place, after all. Chinese and Russian fans of ice and snow sports express warm greetings and sincere wishes to the athletes of the two countries and to the athletes of all countries participating in the Beijing Winter Olympics.

　　A message is full of sincerity, and a blessing is full of sincerity. Although separated by mountains and rivers and with different languages, this Olympic invitation from Beijing transcends the time and space restrictions, and the love for ice and snow sports has become the common language of people from all countries, condensing into a common expectation: to the future together!

　　Producer: Wang Shanshan Admiralty

　　Producer Wang Weixing came to Yan Xi.

　　Editor-in-Chief Li Ying Zhang Weihao Li Jingjing Levin

　　Planning Liu Tianzhe Wang Yinghan Fan Jiachen Chen Ningzeyi

　　Editor Ren Jia Jiang Min Hao Zhihui Cai Mingjun

　　Editing Sudan

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Chengdu residence permit points can be added to the household rules.

　　The good news of warm spring is coming! The "Detailed Rules for the Implementation of Chengdu Residence Permit Points Management Measures (Trial)", which is concerned by the public, was published on the website of Chengdu Municipal People’s Government on March 9, and is valid for two years.

　　As long as you hold a residence permit in Chengdu and meet the relevant conditions, you can participate in the application for points entry. Huaxi Dushi Bao-the cover journalist combed and found that citizens can get corresponding points by doing nine major items such as charity, blood donation and volunteer service, while those with personal bad credit records and illegal crimes will be reduced accordingly.

　　The standard score of the starting line for households is 100 points, and applicants are ranked according to the level of points.

　　The standard score of integral is 100 points. If the total score of residence permit reaches the standard score and meets the following conditions at the same time, you are eligible to apply for points:

　　The applicant holds the residence permit of this city (within the validity period), and the age is under 55 for men and 50 for women. The applicant has paid the basic old-age insurance for urban workers and the basic medical insurance for urban workers for more than 5 years in accordance with the relevant provisions of the state, province and city within the administrative area of this Municipality. At the same time, he has no criminal record and has not participated in organizations or activities prohibited by the state.

　　The annual residence permit points into the household index plan, released after examination and approval by the municipal government. Within 10 days after the announcement of the results of the points, Chengdu Population Service Management Office will rank the points in the order of high and low according to the application of the holders who have reached the standard score, and rank the points with the same points according to the years of participation and residence, and determine the list of households according to the annual residence permit points entry index plan, which will be publicized on the website of Chengdu residence permit points public service platform for five days.

　　Nine items plus points

　　You can get extra points by adding 25 points for charity volunteer service at the highest time.

　　In what areas should the applicant score points? Chengdu has listed nine points, many of which are "sub-items". As long as applicants have stable housing, occupation and social security, they can get points. Among them, the highest individual score is awarded by the state, with 25 points at a time.

　　　Pay social insurance index

　　If the applicant participates in the basic old-age insurance and basic medical insurance for urban workers in accordance with the relevant provisions of the state, province and city within the administrative area of this Municipality, and continuously pays the monthly fee for 12 months, 10 points can be accumulated; If it is over 6 months but less than 12 months, 5 points will be accumulated; No points for less than 6 months.

　　Legal and stable residence index

　　The applicant actually lives in the house in this city, and obtains the own residence with the property right certificate or the house ownership certificate, plus 10 points, and the continuous residence is calculated by 1 point/year; The housing that has signed a formal housing lease contract and gone through the lease registration and filing shall be counted as 1 point/year for continuous residence. If there are two or more self-owned residences and rented houses within the scope of this Municipality, only the houses with the same residence permit address can be added, without accumulation.

　　Educational background index

　　Applicants who do not meet the requirements for talent introduction in this Municipality, but have obtained full-time colleges and universities recognized by the Ministry of Education and other part-time higher education colleges (including higher vocational colleges) or above, add 10 points.

　　Indicators to guide the rational distribution of population

　　Since January 1, 2018, the applicant has participated in social insurance for urban workers in the social security agencies of provinces, cities, districts (cities) and counties within the administrative area of this Municipality, and the registered place of the employer (including individual industrial and commercial households) is calculated cumulatively at 20 points/year in the eastward area and the southward area, and 10 points/year in the northward area, with no extra points in other areas.

　　Guiding population gradient transfer index

　　Since January 1, 2018, if the applicant’s residence is transferred from Jinjiang District, Qingyang District, jinniu district, Wuhou District, chenghua district and Chengdu High-tech South Zone and West Zone to other administrative areas of this Municipality, 5 points will be added for each full year; If the applicant’s place of employment and residence are transferred to other administrative areas of this Municipality, 10 points will be added for each full year.

　　　Urgent need for indicators of jobs (occupations)

　　If the applicant belongs to the catalogue of urgently needed jobs (occupations) in this Municipality, add 10 points.

　　Individual contribution index

　　Individual contribution indicators are divided into five aspects:

　　Applicants who have been commended by the Party committee or government of the country, Sichuan Province and Chengdu City will be awarded 25 points at the national level, 20 points at the provincial level and 15 points at the municipal level respectively, and the above points will not be accumulated. Including model workers (including those who enjoy the treatment of model workers), moral models, courageous models, craftsmen, etc.

　　The applicant pays personal income tax in this city according to law, and if the annual tax payment in the previous natural year reaches 10,000 yuan, add 2 points; If it exceeds 10,000 yuan, it shall be calculated by adding 0.2 points for every 1,000 yuan, with a maximum of 10 points.

　　Applicants who participate in volunteer service are registered in Chengdu Volunteer Network (APP) with their real names and obtained the length of volunteer service. The application points are accumulated for 25 hours of volunteer service in the previous natural year plus 2 points, and 1 point is added for every 2 hours after reaching 25 hours, with a maximum of 10 points.

　　Applicants who participate in charitable donations within the scope of charitable organizations registered in this Municipality can get extra points. Donations of funds or materials (equivalent to RMB) in the past 3 years will be calculated by adding 2 points for each full RMB 1,000, with a maximum of 10 points.

　　The applicant shall add 2 points for each donation of 200ml whole blood, 1 point for each increase of 100ml whole blood, and 2 points for each donation of a therapeutic amount of apheresis platelets from June 1st to May 31st of the reporting year, with a maximum of 10 points.

　　Encourage innovation and entrepreneurship indicators

　　Applicants who participated in the Innovation and Entrepreneurship Competition won national, Sichuan or Chengdu municipal awards, with 15 points, 10 points and 5 points respectively; The applicant in the city to start a business to absorb more than 5 people employment plus 10 points; If the applicant invests or starts a business in this city’s science and technology business incubator and Zhongchuang Space, 10 points will be added if certain conditions are met.

　　Age index

　　If the applicant is under 45 years old, add 10 points, and the deadline for calculating the age is May 31st of the year when applying for points.

　　Decrement index

　　50 points for illegal crimes at a time.

　　Personal bad credit records, personal criminal records, etc. will be reduced.

　　Personal bad credit record index refers to the applicant’s bad records in personal credit, industrial and commercial taxation and other aspects in the past three years, with 10 points deducted for each item. Individual criminal record index refers to the applicant who violates relevant laws and regulations, is punished for criminal offences, and participates in organizations or activities prohibited by the state, with 50 points deducted for each item; By the administrative law enforcement organs sentenced to administrative detention, compulsory detoxification, each minus 20 points.

　　Violation of family planning policy indicators, illegal birth behavior reduced by 50 points.

　　Detailed question and answer

　　Guide the population to rationally distribute the three bonus areas.

　　In guiding the rational distribution of population, which specific areas can be added?

　　The specific bonus areas are: Dongjin area (the trial scope includes Tianfu International Airport New City, Jianzhou New City and Huaizhou New City); Nantuo area (the trial scope includes Luxi Zhigu Science and Technology Innovation and High-tech Industrial Service Functional Zone in Tianfu New District, Tianfu Center Headquarters Economic Functional Zone in Tianfu New District, Tianfu Center International Convention and Exhibition Functional Zone in Tianfu New District, Tianfu New District Southern District Industrial Park and Tianfu New District Qionglai Industrial Park); Northern Reform Area (the trial scope includes qingbaijiang district Advanced Materials Industrial Park, qingbaijiang district International Railway Port Service Industry Cluster, Xindu High-tech Industrial Park, Pengzhou Chengdu Aviation Power Industrial Park).

　　How to understand "own residence" and "housing lease" in the index of legal and stable residence?

　　Self-owned residence refers to the housing that has obtained the title certificate of immovable property or the title certificate of house ownership within the city, including the housing owned by the applicant alone or jointly with his spouse, the housing owned by the applicant and others with a share of not less than 50%, and the housing owned by the applicant’s spouse alone.

　　Housing lease, including the state-owned directly-managed public houses rented by the applicant alone or jointly with others, the houses with legal property rights rented by employees, public rental houses (including low-rent houses) and other legally rented houses.

　　How to understand "residence transfer" and "applicant’s employment transfer" in the index of guiding population gradient transfer?

　　The transfer of residence refers to the change of the applicant’s actual residence address, which is subject to the change of address recorded in the residence permit.

　　Transfer of the applicant’s employment place: one is that the registered place of the employer (including individual industrial and commercial households) where the applicant is located is changed from Jinjiang District, Qingyang District, jinniu district, Wuhou District, chenghua district and Chengdu High-tech South Zone and West Zone to other administrative areas of this Municipality, and the social security participation relationship will not change within the scope of Chengdu (including provincial-level agencies); The other is that the applicant’s former employer (including individual industrial and commercial households) is registered in Jinjiang District, Qingyang District, jinniu district, Wuhou District, chenghua district and Chengdu High-tech South Zone and West Zone. After leaving the original employer, the current employer (including individual industrial and commercial households) is registered in other administrative areas of this Municipality, and the social insurance participation relationship has changed in Chengdu (including provincial-level agencies). (Reporter Lai Fangjie)

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CCTV comments that ＂online celebrity＂ cannot touch the social ＂red line＂ no matter how red it is.

Mobile Internet has spread to every corner of people’s lives. When we enjoy the infinite convenience it brings, we also have to face the complicated troubles caused by it. The "information cocoon room" is building consensus barriers, social anxiety is also being amplified, and the network "bubble" is gradually being squeezed by the real society. How to understand and solve these problems and make this great technology better serve human society?

Today, CCTV Online Review launched the fifth in a series of comments on "Puzzlement in the Mobile Internet Age".

In this era of being accustomed to "short-term and quick", attention has become a scarce product.

Having attention means having traffic, and having traffic means having huge profit opportunities.

When all this becomes business, the behavioral logic becomes simple and rude: some people dance at the crossroads where traffic is rolling, some people ride horses in the bustling downtown area, some people broadcast the mother’s funeral live, and some people carry the activities of street hair salons to the Internet to attract audiences … …

In short, driven by money, some money-worshippers, online celebrity, are full of ugliness, and they feed each other with some "bad tastes", just like "cultivating methods" and quenching thirst by drinking poison. Those who show off ugliness are proud of ugliness and do whatever it takes, while those who judge ugliness are empty and don’t distinguish right from wrong, creating an ugly absurd picture. To some extent, the relationship between sender and receiver is alienated into traffic catcher and prey, and the public field is wantonly polluted, full of invalid and even harmful information.

As a result, in this field where traffic can be realized, the supremacy of traffic has become the "belief" of some people, and "attracting attention" has become the "Bible" of many online celebrity.With 10,000 likes, some "online celebrity" can violate scientific laws and basic common sense; With 100,000 likes, he or she no longer cares about social justice and ethics; There are millions of likes, and they even dare to challenge social rules and national laws.

It is human instinct to pursue excitement, entertainment and privacy, but for thousands of years, morality and ethics have been edified, knowledge civilization has been edified and legal norms have been disciplined, and we have always been a higher species from goodness to beauty. Entertainment is innocent, but there should be a bottom line. In a high-speed society, we need a happy place where people can release their pressure and have a good time, but everything can’t be Fiona Fang without rules.

What should be particularly alarming is the bad influence of many bottomless contents on young children. Some "post-00 generation" take online celebrity as their ideal, naively thinking that they can become the so-called "winners in life" just by sitting there, chatting and singing, and even more, they regard the bottomless content as a standard and benchmark, spreading and poisoning society and young children.

Teenagers have not yet formed firm values and have no rational judgment, and their nature is like silk. If they are dyed yellow, they will be yellow, and if they are dyed pale, they will be pale. If you soak in such a pool of muddy water that you are proud of showing off your wealth and ugliness all day, how can you grow a healthy, noble and upright "good seedling"?

In fact, the Internet is not anyone’s bedroom, but a "living room" for public opinions. Online celebrity’s content export is essentially a kind of cultural communication behavior, which should and must bear the corresponding social responsibility and abide by the corresponding laws and regulations.
　
Theoretically, the cleanliness of the Internet environment depends on the conscious self-discipline of the participants, but it is obviously a naive moral imagination to just pin the maintenance of the Internet atmosphere on it. And only relying on "didactic" guidance, the means are too thin.

Therefore, we must find a way to build the system. In advance, it is necessary to clarify the legal "red line", draw a clear moral bottom line, and regulate the "online celebrity" behavior with laws and regulations; In the event, it is necessary to strengthen supervision, achieve "full coverage", and promptly clean up harmful content and illegal personnel; After the event, it is necessary to make clear the responsibility and be serious and car-scrapping, especially for extreme events that have had a bad influence on society, and to impose heavy penalties and heavy responsibilities, and at the same time, establish a "blacklist" system to make waves and wash sand against the illegal "online celebrity".

What is more noteworthy is that online celebrity’s chaos and bottomless content are problems of values, which reflect money worship, excessive entertainment and empty faith. Therefore, it is necessary not only to carry forward the excellent traditional culture of the Chinese nation, but also to be targeted in education, so as to lay a solid foundation for the majority of netizens, especially minors, and make it difficult for those bottomless network contents that are "squandering flowers and getting attractive".

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Can the ＂sugar control＂ rice cooker help you control your blood sugar？

　　Recently, a new type of rice cooker with "sugar control" function suddenly caught fire. Some say that it can make germinated brown rice, and the blood sugar reaction after meals is low; Others say that it can drain some sugar and increase the resistant starch of rice. Many netizens asked: Is there such a good thing?

　　Some popular science people have expressed their opinions, arguing that these statements are exaggerated propaganda and lack of scientific basis. Although there is some truth in these criticisms, I think that it should be encouraged that domestic electrical appliance enterprises can adapt to the development of the times and develop new products with the goal of promoting healthy eating of residents. Whether it is to help people eat germinated brown rice, or to help people cook miscellaneous grains rice easily, or to consider the problem of reducing postprandial blood sugar response in designing cooking procedures, it is very meaningful.

　　Next, let’s discuss rice cookers and controlling postprandial blood sugar in four questions.

　　Rice cooker capable of making germinated brown rice

　　Is it good?

　　Brown rice (including light-colored, red and black unrefined rice) belongs to whole grains, and its contents of vitamins B1, B2, potassium, magnesium and other nutrients are 2-3 times that of polished rice, and its dietary fiber content is also several times. Therefore, many countries, including Japan, South Korea and some European countries, advocate replacing some foods made of white rice and white flour with brown rice.

　　When brown rice germinates γ -The content of aminobutyric acid is increased. It is the most important inhibitory neurotransmitter in the nervous system and plays a certain role in improving stress and emotional disorder.

　　When brown rice germinates, the phytic acid content will decrease, and the mineral utilization rate of the outer layer of brown rice will increase. In the case of slight germination (for example, the bud length is less than 2mm, but the germ is just exposed), the contents of protein and carbohydrate have little change, and vitamins and minerals can also be retained.

　　Phytic acid is also a substance that can inhibit the activity of digestive enzymes. Germination reduces phytic acid, and the cooking conditions are precise, which can improve the taste of brown rice after cooking and make it easier for the elderly, children and indigestion.

　　From this point of view, if you used to eat only white rice, but you really plan to eat germinated brown rice in the future, an electric cooker with this function is still worth buying.

　　After all, rice is the food that most people eat the most every day. If the nutritional quality of rice can be effectively improved, its health significance can not be ignored after a long period of time.

　　However, whether diabetics can help control postprandial blood sugar after eating germinated brown rice cooked in this pot, I haven’t seen the measurement data yet, so I’m not sure for the time being.

　　Studies have shown that the GI value (glycemic index) of brown rice without germination can be as high as 82, which is close to the value of white rice, when it is soaked overnight and cooked fully and eaten while it is hot. If it is glutinous rice brown rice, and after a night of pre-soaking, its GI value may be higher.

　　Although this kind of rice cooker uses technical treatment to shorten the germination process of brown rice to several hours, it has been fully pre-soaked and the rice grains have fully absorbed water. In this case, the germinated brown rice cooked should be soft in texture. If it is eaten while it is hot at that time, it may not be able to effectively reduce the blood sugar level within a few hours after a meal.

　　But even so, people who need to control blood sugar eat this germinated brown rice, which is still more beneficial than ordinary white rice. This is because they not only need to control blood sugar, but also need to improve the overall nutritional status.

　　Compared with healthy people, diabetic patients are more common in vitamin B deficiency, and because they often have polyuria symptoms, the excretion of vitamin B and various minerals in urine will obviously exceed that of healthy people. Lack of vitamin B1 will increase the risk of nervous system complications, and vitamin B1 is a vitamin with low content in white rice.

　　If white rice can be replaced by brown rice, the supply of vitamin B1 from staple food can be doubled or tripled. At the same time, because the potassium content in brown rice is several times that of polished rice, brown rice can increase potassium intake, which is also beneficial to prevent and control hypertension.

　　Therefore, even if the GI value of germinated brown rice is the same as that of white rice, it is still beneficial to the health of diabetic patients in the long run because of its higher nutritional value.

　　"Sugar-draining" rice cooker

　　Can it help control sugar?

　　Another kind of rice cooker called "sugar control" claims that it can reduce "amylopectin" in rice, reduce carbohydrate content and increase resistant starch. Is this principle reliable?

　　I communicated with the company, and they said that they did do starch digestion experiments and human experiments, which proved that the rising speed of blood sugar after meals really slowed down.

　　I agree that this statement of enterprises is not completely without scientific basis.

　　Rice contains amylopectin and amylose. Glutinous rice has less than 1% amylose, so it is very sticky after cooking. Most Chinese likes to eat soft and slightly elastic rice, which belongs to japonica rice (northeast rice and Japanese rice type). Their amylose content ranges from a few percent to more than ten percent, while long-grain indica rice (Thai rice type) has a higher amylose content, and some long-grain varieties can even reach as high as 30%.

　　Previous studies have found that under the same cooking conditions, rice with high amylose content is hydrolyzed slowly under the action of digestive enzymes; Or because of texture factors, chewing is not rotten, and the particles are larger, then the rate of blood sugar rise after meals will be slightly slower.

　　For example, South Asian countries like to eat rice with high amylose content. After students in China go there as exchange students or volunteers, they often feel that the rice there is difficult to digest, and it will take some time to get used to it.

　　This kind of rice cooker dissolves amylopectin which is easy to disperse in water and removes part of it by draining rice soup, leaving a higher amylose content. At the same time, through the control of the cooking procedure, the cooked rice is harder, chewier and slower to digest.

　　Textural properties of food are very important.

　　If the texture is tight, it is difficult to chew thoroughly, and the efficiency of digestive enzymes will be relatively low, so the digestion speed will slow down and the rate of blood sugar rise after meals will decrease. Since the rice cooker cooked the rice hard and removed a part of the starch in the rice soup, the resistant starch increased and the available carbohydrate decreased. When the blood sugar reaction decreased after the meal, these data should be true.

　　In the case of more resistant starch, the human body gets less actual energy, so in the state of free eating, it is possible to automatically increase the food intake from other foods, which may not necessarily reduce the total carbohydrate intake. Even so, resistant starch can improve intestinal flora, which is beneficial to diabetic patients.

　　However, the evidence is short-term, and the effect within a few hours after eating does not prove that the long-term effect of improving blood sugar can be obtained by eating like this. In fact, what I am worried about is the rice soup that has been drained.

　　There is more than starch in rice soup. Other soluble components, such as potassium, vitamin B1, vitamin B2, vitamin B6, etc., have also been removed together with rice soup. These ingredients in white rice are already few, and it is even more pitiful to remove some, and the nutritional value of rice has become even lower. As mentioned earlier, these ingredients are very important for diabetic patients to prevent various complications.

　　Therefore, if you want to eat this "sugar-drained" rice, you need to add some extra B vitamins (because vitamin B1 is particularly important for carbohydrate metabolism, it is best to eat it with starch foods) and add some vegetables with less salt to supplement potassium.

　　These sugar-controlled rice cookers

　　What are the real benefits?

　　In fact, the real benefits of these rice cookers have been ignored by people — — They can all cook miscellaneous grains rice. Regardless of germination or not, cooking miscellaneous grains rice can improve the nutritional quality of staple food.

　　Those who realize that the instant white rice is unhealthy can make full use of its miscellaneous grains rice function to cook black rice rice, oat rice, quinoa rice, mung bean rice and other miscellaneous grains rice for diabetics. They not only have more resistant starch, but also the contents of vitamins, minerals, dietary fiber and antioxidants will increase several times or even ten times. This can not only help control sugar, but also help prevent hypertension, hyperlipidemia and fatty liver, and help prevent various diabetic complications.

　　As for the sugar sieve, it doesn’t matter if you don’t use it, but it can also be used reasonably.

　　People with normal blood sugar but high blood pressure can use rice soup instead of salty soup at meals, which tastes better and can add some potassium; People with normal blood sugar but poor digestion can also drink rice soup as appetizing soup before meals, which is beneficial to the secretion of digestive juice.

　　Rice cooked by sugar-controlled rice cooker

　　Can I "eat with my heart open"?

　　As we all know, whether a food is good for health has a great relationship with its intake and food collocation. It is beneficial to replace a bowl of white rice with a bowl of germinated brown rice, but it does not mean that it is also beneficial to eat several bowls. Diabetic patients need to eat enough carbohydrates, but their total amount still needs to be properly controlled.

　　Therefore, it is obviously not very accurate to say that "there is no need to limit the amount of germinated brown rice cooked in this rice cooker". Besides, it is impossible to completely solve the problem of "three highs" by relying on only one kind of food, and there is no need to expect too much.

　　Similarly, for a "sugar-drained" rice cooker, it cannot be said that as long as the rice cooked by it is eaten, there is no need to limit the amount of staple food. It’s just hard-boiled rice. It is estimated that even if you want to eat more bowls, you will be a little tired when chewing. Just be careful not to eat biscuits and snacks between meals because the digestibility of rice is low and the blood sugar is too low.

　　In a word, my opinion on rice cookers with "sugar control" is as follows:

　　1. This kind of rice cooker provides consumers with many cooking possibilities, and the efforts of cooking electrical appliances enterprises are worth encouraging.

　　2. Germinated brown rice does not necessarily have a low glycemic index, but its nutritional value is indeed much higher than that of rice, which is worth eating by the whole family.

　　3. The digestion speed of "sugar-drained" rice is really slow, and the resistant starch increases, but the nutritional value decreases, which is not the best scheme to control sugar. If you want to eat, it is recommended to supplement B vitamins and increase the number of vegetables with less salt.

　　4. This kind of rice cooker can be reasonably used to make mixed rice of rice and miscellaneous grains, including germinated brown rice. It would be great if we could increase the acceptance of the whole family’s staple food of whole-grain miscellaneous beans.

　　For cooking appliances such as rice cookers and electric pressure cookers, the most important thing is to make their functions convenient for healthy eating and increase the possibility of people eating whole grains. What the merchant says is not the most important thing, but how to make good use of it after you buy it yourself.

　　Text/Fan Zhihong (Director of China Nutrition Society)

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