标签归档 上海419论坛2021

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Focusing on Drug Targets: "Fighting poison with poison" —— The latest research progress of oncolytic virus

Since the 19th century, virus therapy for cancer has been studied. However, due to technical barriers and safety problems in genetic engineering, great progress has not been made until the last 20 years. At present, viralvectors for gene therapy and oncolytic viruses (OVs) are the main methods used by viruses as tumor therapy. The main difference between gene therapy virus vector and OVs is that the virus used in gene therapy virus vector is a non-replicating virus, while the vector used in OVs is a virus with replication ability.

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OVs refers to a kind of viruses that can selectively infect and kill tumor cells without damaging normal cells, and they often have good tumor lysis and targeting. OVs can replicate in the host cell after infecting tumor cells, and the released progeny viruses can continue to infect surrounding tumor cells, at the same time activate local or systemic anti-tumor immune effects, change tumor microenvironment and further improve anti-tumor effects. Natural oncolytic virus has some limitations, such as inconsistent safety or weak ability to stimulate the body to produce tumor immunity. In order to overcome the above shortcomings, oncolytic virus vector came into being: it not only retains the ability of oncolytic virus to kill tumor cells, but also enhances its efficacy of activating immune response after genetic modification.

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From non-gene editing type to gene editing type, OVs contains many kinds and characteristics. According to the different nucleotide types of virus genome, OVs vectors can be divided into DNA virus vectors and RNA virus vectors. Among them, the main DNA viruses are herpes simplex virus (HSV), adenovirus (AdV), vaccinia virus (VV) and H1(parvovirus H1. RNA viruses are mainly reovirus (RV), coxsackie virus (CV), poliovirus (PV), measles virus (MV), NDV and vesicular stomatitis virus (VSV).

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The latest research progress

1. At present, five products have been approved for listing in the world, and it is predicted that they will reach the market of over 10 billion dollars in the future.

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2. According to the data of Toubao Research Institute, the market size of oncolytic drugs in China will continue to grow at a compound annual growth rate of 16.2%, and it is expected to rise to 1.43 billion yuan by 2024.

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3. According to the number of research targets, they are IL-12, GM-CSF, PD1, IL-15, PDL1, CD, CD19, CTLA4, NIS, etc.

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4. In the research enterprises, among them, there are many researches and developments on oncolytic viruses, such as Icell Kealex Therapeutics(10), Cell Genesys(7), Virogen Biotechnology (6), PsiOxusTherapeutics(5), Transgene(5) and Jennerex(4). In addition, domestic enterprises such as Innomicro, Synbiotics, Shanghai Medicine, Ruotai Medicine, Kangwanda Medicine, Saibainuo, Lepu Bio, Tasly, and Funuojian are also deployed in this field.

5. Statistics of drugs currently in clinical research stage are as follows:

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Introduction of key drugs

Among the five oncolytic viruses approved worldwide, including picornavirus Rigvir, which is approved for the treatment of melanoma in Latvia; Secondly, today’s reborn (recombinant human P53 adenovirus injection) and recombinant human adenovirus type 5, which were approved in 2004 and 2005 respectively, were approved for the treatment of solid tumors such as hepatocellular carcinoma, nasopharyngeal carcinoma and pancreatic cancer. In 2015, the United States and Europe approved the engineered herpes simplex virus (HSV-1) of talimogene laherparepvec(T-VEC) for the treatment of unresectable metastatic melanoma. Finally, in 2021, Japan approved the improved herpes simplex virus teserpaturev for the treatment of brain cancers such as glioblastoma. The statistic of some drugs in that lead stage of clinical development are as follows:

1、CG0070

CG0070 is a genetically modified adenovirus type 5 (Ad5), which contains cancer selective promoter E2F-1 and immune cell stimulating factor GM-CSF gene, and selectively replicates and lyses tumor cells in Rb-deficient tumor cells. The rupture of cancer cells will release tumor-derived antigen and GM-CSF expressed with the virus, thus stimulating systemic anti-tumor immune response. CG0070 was introduced by Lepu Bio from CG Oncology in the United States, and obtained its product development rights and global supply rights in China; Except China, the rights and interests in Japan, South Korea, China, Taiwan Province and other Asian countries were acquired by Kissei Pharmaceutical.

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2、Pelareorep

Pelareorep(AN1004) is a non-pathogenic reovirus introduced by Oncologics Biotechnology by Arnold Pharmaceuticals. It can overcome the neutralizing antibody, selectively infect and destroy tumor cells by activating the body’s own immune system, and is used to treat various solid tumors and hematological malignancies. Pelareorep is a rapidly developed oncolytic virus product that can be administered by intravenous injection in the world. The second phase clinical trial of Pelareorep in the treatment of metastatic breast cancer found that the overall survival rate of patients with ER+PR+/HER2- breast cancer was doubled (21.8 months vs. 10.8 months). In its global phase II clinical trial (BERIL-1) for the treatment of head and neck squamous cell carcinoma (HNSCC), the median survival time of patients was as high as 10.4 months. In March, 2022, Oncologics Biotechnology announced that it had completed the safety assessment of three patients in the metastatic colorectal cancer (mCRC) cohort of the oncolytic virus Pelareorep phase 1/2 GOBLET study.

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3、pexastimogene devacirepvec

Pexastimogen devacirepvec (JX-594) is a genetically engineered vaccinia virus introduced from abroad by Lee’s Pharmaceutical Factory. Its TK gene is mutated, and human GM-CSF gene is inserted to enhance the anti-tumor immune response. The advantages of using vaccinia virus include the stability of intravenous infusion, strong cytotoxicity and the safety of classical live vaccine. Previously, the drug had poor clinical performance in phase III of hepatocellular carcinoma, and the efficacy of the drug in combination with cemiplimab in the treatment of renal cell carcinoma is currently being evaluated.

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4. Naomi Loki

Loki (GL-ONC1, Olvi-Vec) was developed by Genelux Company, and Hengyi Bio owns its development rights in Chinese mainland. It is an oncolytic vaccinia virus. Three expression cassettes encoding β-galactosidase, β-glucuronidase and renin luciferase/green fluorescence (RLuc-GFP) fusion proteins are used to replace virus TK, hemagglutinin and F145L genes respectively. A phase I clinical trial of GL-ONC1 in patients with head and neck cancer showed that intravenous injection of GL-ONC1 combined with standard chemotherapy could improve the overall survival rate. This study also proved the safety of the virus.

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5、OH2

OH2(BS001) is the first candidate drug for oncolytic virus in the world, which is independently developed by Binhui Ib/II-tech, and has chosen HSV2-2 as the carrier and entered clinical trials. Clinical data show that the objective remission rate (ORR), disease control rate (DCR) and one-year survival rate (OS) of BS001 are 30%, 50% and 50%, respectively. In addition, the latest clinical data in the treatment of colorectal cancer show that the objective remission rate of BS001 injection in the treatment of colorectal cancer patients has exceeded 10%. The objective remission rate of BS001 injection combined with PD-1 monoclonal antibody was 18.2%.

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prospect

In recent years, with the development of genetic engineering technology, people have a deeper understanding of the function and structure of virus genes. Optimizing the design and operation of virus genome to produce non-pathogenic viruses has become the research direction of oncolytic viruses, which has greatly promoted the progress of oncolytic virus therapy. Combined treatment of oncolytic virus with chemotherapy or immunotherapy drugs, or even combined application of multiple oncolytic virus drugs, may control tumor progression or cure tumor more effectively, and provide potential clinical treatment options for tumor patients. We believe that with the deepening of oncolytic virus research, oncolytic virus therapy will play a wider and deeper role in treating human diseases.

references

Yang Hao, Zhang Shaogeng, Yang Penghui. Immunological mechanism and clinical research progress of oncolytic virus [J/OL]. Progress in biochemistry and biophysics: 1-16.

[2] Liu P, Wang Y, Wang Y, et al. Effects of oncolytic viruses andviral vectors on immunity in glioblastoma[J]. Gene therapy, 2020: 1-12.

[3] Kaufman H L, Kohlhapp F J, Zloza A. Oncolytic viruses: a newclass of immunotherapy drugs[J]. Nature reviews Drug discovery, 2015, 14(9):642-662.

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Skyworth EV6 2024 520 Deluxe Edition models listed: pure electric battery life 520 kilometers, sales 306,800 yuan

 On March 28, it was reported that the 2024 Skyworth EV6 520 Deluxe Edition model is currently available.

IT House noted that the front face features a closed air intake grille, claiming to use the modern "Bauhaus" design concept, and is equipped with matrix laser headlights and through-the-tail light sets.

▲ Picture source, Skyworth Automotive official website (the same below)

In terms of the cockpit, the overall color of the interior of the 2024 Skyworth EV6 520 Deluxe Edition is black/brown, and chrome-plated elements are added for embellishment. It is equipped with a 12.8-inch central control and supports 360-degree reversing images, rear parking radar, LED headlight set, four-door window one-click lift, electric tailgate, leather steering wheel, automatic air conditioning, reversing images, and tire pressure monitoring.

In terms of parameters, the car’s length, width and height are 4720/1908/1696 mm, with a wheelbase of 2800 mm. The 2024 Skyworth EV6 520 Deluxe Edition is equipped with a single front motor, with a maximum power of 150 kW and a maximum torque of 320 Nm.

In terms of battery life, the car is equipped with a 71.98 kWh ternary lithium battery, with a pure electric battery life of 520 kilometers under NEDC conditions.

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Jordan chan filmed "Rhapsody of BMW", and Cherrie Ying had a magic prescription for her husband.


Jordan chan’s "Rhapsody of BMW" started to worship God.


Jordan chan


"Rhapsody of BMW" crew


Jordan chan, Xiong Naijin.

 

  The film "Rhapsody of BMW" has been quietly filmed in Chongqing for several days. On March 2nd, the crew held a worship ceremony, and opened a visiting class for the first time. Director Kirin and starring Jordan chan, Xiong Naijin, Cheung Yung, Peng Bo, Liang Jiaren and Li Jianren all made their appearances. The film is the first film he made after Jordan chan and Cherrie Ying got married, so the topic on March 2 was of course focused on Jordan chan. Coincidentally, Xiong Naijin, Cherrie Ying’s good sister and Chongqing’s younger sister, plays the role of Jordan chan’s wife in the film. The two of them exchanged words at the scene, but the way Jordan chan and his wife got along was completely exposed.

Way to get along 1: One stresses hygiene.

The other one followed.

  Jordan chan and Xiong Naijin played a couple, Liu Zili and Hu Mo, and their communication style was also very comic. A few days ago, they filmed a scene in the elevator on Kaixuan Road, which attracted a large number of Chongqing citizens to watch. It was Jordan chan who rushed up hundreds of steps with Xiong Naijin in his arms. As a result, 10 scenes were filmed in a row, and Jordan chan was exhausted. Therefore, the next day, Xiong Naijin specially bought Chongqing’s specialty beef to "replenish his strength" for Jordan chan.

  Xiong Naijin said with a smile: "When I saw Jordan chan before, I always thought he was a cool person, but I didn’t know that I was very happy and cute." She also said that she had attended the wedding of Jordan chan and Cherrie Ying. I "cried all the time and got a flower ball. Their joy and sweetness in love moved people around me." Jordan chan joked that "you have been throwing up", and Xiong Naijin immediately answered: "Yes, because they both drink a lot, I can’t."

  However, Hume in the film always makes his home a mess like a kennel. Jordan chan said that he can’t stand this. As for real life: "My family loves hygiene very much."

Way to get along: making money to support your family is king.

  On March 2nd, Jordan chan appeared in front of reporters in a suit and tie, but he admitted that he "hates wearing a suit. I feel stupid, but some people say I am handsome. This filming, it is unnatural to wear a suit on the first day, and it will be OK slowly. "

  Shortly after getting married, he devoted himself to the filming of "Rhapsody of BMW", and then he was busy with the propaganda completed before shooting. He said that the main reason for taking the filming of "Rhapsody of BMW" was that the planner Li Jianren (the supporting role of the gold medal in Xingye’s movie "Flower") had been talking to him about this play for half a year, and the sincerity of the film moved him; However, Jordan chan also has his own ideas: "To be honest, there is really no need to film like this (to support the family), and even we don’t have much time to meet. But when I think that many people have no jobs and I have this opportunity, why not do it? So don’t think so much, just do it well. "

Way to get along 3: Give up bad hobbies for your wife.

  Jordan chan used to like riding motorcycles: "I have two motorcycles, because no one knows you with a mask on. You can speed and feel free. " However, this activity, because Cherrie Ying felt very dangerous, Jordan chan also automatically reduced.

  What everyone is most concerned about is that Mrs. Chen Cherrie Ying can be promoted to be a mother for a long time, so Jordan chan will inevitably be asked about her plans to have children. Jordan chan is another funny smiling face: "She is under great pressure, and her sisters have both given birth or gone up (at the same time, everyone is surprised that what he said was pregnant). Also, whether to have a boy or a girl, she is very entangled. "

  However, he changed the subject: "If there is no plan to have children, why are you getting married?" So it must be born. But giving birth to a child is not a raw egg … … You don’t have to worry about us, we will plan well. "

Way to get along 4: Never forget to take a vaccination at all times.

  Even before Jordan chan joined the group, Cherrie Ying "called" his good sister Xiong Naijin from a distance in Weibo: "Take a good look at my husband". Asked about this topic on March 2nd, Xiong Naijin laughed: "In fact, this is the way of communication between husband and wife, which is very happy and festive".

  However, since he has been invited, Xiong Naijin certainly has to exercise his "duty": "So every time I talk to Koharu, you have to go out to play, you can, but you have to take me." And Cherrie Ying’s biggest killer is a VCR recorded by himself, "Anyway, every time Koharu misbehaves, I will show it to him, hahaha". Therefore, Xiong Naijin admired Cherrie Ying: "I have been saying that it is time for you to write a book" Yu Fu Jing "."

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The movie channel will hold a charity gala where Jackie Chan kisses the donated patients


Jackie Chan embraces Xiao Yonghua


Jackie Chan kisses Little Yonghua’s face


Jackie Chan presented the love schoolbag to Xiao Yonghua

  Movie Network News(Photo/Qian Jia’s memoir/Yang Yaru) "Believe in Love – 2012 New Year’s Charity Gala", co-organized by Movie Channel, China Social Assistance Foundation and Beijing Jackie Chan Charity Foundation, and organized by Movie Network (www.1905.com), will be grandly held in Beijing on December 17. The donations from this charity gala will be invested in two charity projects: "Treatment Project for Poor and Seriously Sick Children" and "Education Assistance Action for Poor Students" to help poor families regain hope. At that time, Jackie Chan, Huang Xiaoming and other 100 movie stars and many entrepreneurs will be present to do good deeds. A few days ago, Yang Yonghua, a donated child, arrived in Beijing for free treatment. Jackie Chan also offered a kiss. [Movie Network] The video directly touched the whole process.

  On the afternoon of December 8, Xiao Yonghua from a poor family in Hualong Hui Autonomous County, Qinghai Province, accompanied by the staff of the movie channel "Premiere", flew from Hualong to Beijing, and two members of the New Seven Xiaofu personally went to the capital airport to pick up the plane. Xiao Yonghua, who had never left her hometown, seemed very nervous. She was silent along the way. New Seven Xiaofu sang children’s songs, provided snacks, and kept introducing Beijing attractions to her, doing her best to eliminate Yonghua’s defensive psychology. After a while, the car drove to Huairou China Film Base, where Jackie Chan, who was filming the movie "Zodiac", personally welcomed Xiao Yonghua’s arrival.


Jackie Chan is directing the filming on the spot, and Xiao Yonghua is sitting behind Jackie Chan and watching it carefully


Jackie Chan touched Xiao Yonghua’s head and seriously asked about her condition


Xiao Yonghua walked out of the passenger exit accompanied by his grandfather. This is also the first time Xiao Yonghua has come to the capital Beijing


Two members of New Seven Xiaofu came to welcome Xiao Yonghua


The two dragged Xiao Yonghua to the parking lot

  When filming, he still looked stern. After seeing Yonghua, Jackie Chan suddenly became gentle, immediately carried her to the chair, and asked her softly whether she was cold or thirsty. Jackie Chan moved the electric heater to Yonghua more intimately, for fear that she would be frozen. Jackie Chan directed the play while insisting on taking care of the children. The day was just in time for the filming of a major explosion in "Zodiac", Jackie Chan personally checked the explosion point. Although he was highly nervous, he did not forget to tell the staff to help cover Xiao Yonghua’s ears so as not to scare her.


Xiao Yonghua arrived at the Armed Police General Hospital, and Xiao Yonghua’s attending physician and head nurse came to greet him


The children in the same ward also came to help Xiao Yonghua change his hospital clothes


The attending doctor helped Xiao Yonghua do a simple examination

  Little Yonghua’s grandfather told Jackie Chan that Yonghua is 6 years old and suffers from congenital heart disease. She often can’t catch her breath and can’t run like other children. This disease also affects Yonghua’s development. She is much shorter than children of the same age. Jackie Chan held the little girl with pity and offered kisses, telling Yonghua not to be afraid, and that she will be cured soon. Jackie Chan showed his fatherly side that day and gave Yonghua schoolbags and clothes. Jackie Chan also appealed at the scene, "There are still many children in China who are seriously ill like Yang Yonghua. I hope all Chinese people, especially filmmakers, will take action to help them!"

  That night, Xiao Yonghua was sent to the Armed Police General Hospital, where she will undergo heart surgery. This time, Xiao Yonghua’s visit to Beijing and the treatment costs are all borne by the Movie Channel and the Jackie Chan Charity Foundation. Xiao Yonghua’s grandfather said excitedly, "I am very grateful to the kind people who helped Yonghua!"

  On December 17, the "Believe in Love – 2012 Movie Channel’s" Premiere "New Year’s Charity Gala" held by Movie Channel will strive to build a film industry public welfare platform, through the appeal and influence of Chinese filmmakers, to inspire and unite the whole society’s attention to charity and public welfare undertakings. The cost of the event is fully funded by the organizer Movie Channel and [Movie Network], so 100% of the proceeds raised from the auction that night will be used for charity projects. At that time, more children in need will be rescued like Yang Yonghua.

More exciting content on the next page

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BYD Qin L was officially unveiled or listed at the Beijing Auto Show.

Recently, the brand-new model Qin L was officially unveiled. This car will go hand in hand with Qin PLUS to meet the diversified needs of the market. Qin L is expected to sell for more than 120,000 yuan and will be officially listed at the auto show on April 25th.

In terms of design, Qin L shows the unique charm of "the aesthetics of the new country’s tide and beauty". Its large-size front grille is decorated with lattice elements, with long and narrow headlights and rising luminous "dragon beard", which makes the front of the car more stereoscopic and visual impact. On the side of the car body, the elegant waistline extends from the front fender to the back door, and the slip-back design adds more sense of movement to it. The penetrating taillight design at the rear of the vehicle is inspired by the Chinese knot in the traditional culture of China, which is highly recognizable.

In terms of size, the length, width and height of Qin L are 4830mm, 1900mm and 1495mm respectively, and the wheelbase is 2790 mm. Compared with the current Qin PLUS, the size has been significantly improved.

Inside the car, Qin L’s interior design perfectly combines the inspiration of China landscape painting with modern technology. The embedded large-size LCD instrument panel and the iconic rotatable central control screen are full of science and technology. At the same time, the new car is also equipped with a newly designed three-spoke and wireless mobile phone charging function, which further enhances the convenience of use.

In terms of power, Qin L will be equipped with a system consisting of a 1.5L engine and an electric motor, adopting BYD’s advanced fifth-generation DM-i hybrid technology. The maximum power of the engine is 74 kW, and the maximum power of the motor is as high as 160 kW. In addition, the new car is also equipped with a battery from Fudi, Zhengzhou, which provides two battery capacity options, supporting 90km and 60km of pure electric mileage respectively.

Generally speaking, the official appearance of BYD Qin L has brought more choices to consumers. Its unique design, spacious interior space and advanced power system make it more competitive in the same class. I believe that after the official listing of Beijing Auto Show, Qin L will achieve good market performance.

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What is the difference between pure water, mountain spring water and mineral water? What kind of water is more nutritious and healthy to drink?

Original Meimei High Quality Life Jia

Usually when we go to the supermarket, the shelves are filled with all kinds of bottled water. Many people don’t know the difference between them. Even many people think that bottled water is mineral water, but it is not like this. Different bottled water is not only different in brand, but also different in type.

Bottled water is generally divided into pure water, mountain spring water and mineral water, so what’s the difference between them? Which kind of water is more nutritious? Let’s take a look together ~

Mineral water is usually taken from deep underground, and it needs groundwater that has not been artificially treated and polluted. Generally, such water is mostly weakly alkaline water, and it contains certain minerals and trace elements. The chemical composition of mineral water will be affected by other natural factors such as groundwater infiltration environment and water temperature, but it is also relatively stable.

The taste of mineral water is hard. Generally, if it is boiled, it will scale. If it is used to make tea, it will affect the soup color and taste of tea.

Pure water is the water from our rivers, that is, tap water, which is purified by process equipment. The minerals, organic components, harmful substances and microorganisms in the water are all filtered, and there are almost no minerals. Basically, only water is left, and generally the water source is not marked.

Mountain spring water, also known as natural water, is between the above two, removing impurities and harmful substances in the water, and retaining trace elements and a small amount of minerals. Generally, it is taken from surface water, spring water and artesian well water with good environment, no pollution and stable PH value and water temperature. The taste is delicate and silky, and the water quality is soft, which is more suitable for making tea and soup.

Do you understand the difference between the above three kinds of bottled water? Look at the bottled water that you often drink at home. Which one does it belong to?

Finally, what Xiaobian wants to say is that although they are all drinking water, they are all "water". I still suggest that you don’t quote a certain bottled water for a long time. When you buy it next time, you can drink another one!

Original title: "What is the difference between pure water, mountain spring water and mineral water? What kind of water is more nutritious and healthy to drink? 》

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Good! Meet the reasonable financing needs of real estate enterprises with different ownership equally

  China Securities Network News (Reporter Yu Xiangming) According to china construction news WeChat WeChat official account News, on the morning of January 26th, the Ministry of Housing and Urban-Rural Development held a deployment meeting of urban real estate financing coordination mechanism. Party Secretary and Minister Ni Hong attended the meeting and stressed that the spirit of the Central Economic Work Conference should be thoroughly implemented, the coordination mechanism of urban real estate financing should be accelerated to take effect, the development and construction of real estate projects should be supported, the reasonable financing needs of real estate enterprises with different ownership systems should be met equally, and the stable and healthy development of the real estate market should be promoted.

  The meeting pointed out that the establishment of urban real estate financing coordination mechanism is an important measure to implement the decision-making arrangements of the CPC Central Committee and the State Council, meet the reasonable financing needs of real estate enterprises with different ownership equally, and promote a virtuous circle of finance and real estate. The people’s governments of cities at or above the prefecture level should effectively play a leading and coordinating role, quickly establish and operate this important mechanism, timely judge the local real estate market situation and real estate financing needs, strengthen overall planning, refine policies and measures, build a communication platform between government, banks and enterprises, promote the accurate docking of real estate enterprises and financial institutions, and coordinate and solve the difficulties and problems existing in real estate financing.

  The meeting emphasized that the orderly development and construction of the project is the basis for the stable and healthy operation of the real estate market and is related to the vital interests of the people. In view of the current financing problems of some real estate projects, all localities should focus on projects, study and put forward a list of real estate projects that can be given financing support, coordinate the issuance of loans by financial institutions within their respective administrative regions, and accurately and effectively support reasonable financing needs. Credit funds should be ensured to be operated in a closed way and used in compliance, and misappropriation should be resolutely prevented. At the provincial level, it is necessary to track and monitor the implementation and strengthen supervision and guidance. At the national level, an information platform for urban real estate financing coordination mechanism projects will be established, and weekly scheduling and monthly notification will be implemented.

  The meeting demanded that we should adapt to the new situation that the relationship between supply and demand in the real estate market has undergone major changes, speed up the construction of a new model of real estate development, combine the long and short, treat both the symptoms and the root causes, and promote the stable and healthy development of the real estate market. It is necessary to adhere to the policy of the city, precise policy, one city and one policy, make good use of the policy toolbox, and fully give urban real estate regulation and control autonomy. Cities can adjust their real estate policies according to local conditions. It is necessary to work out the housing development plan, improve the housing supply system of "guarantee+market", establish a new linkage mechanism of people, housing, land and money, improve the basic system of housing life cycle, implement the construction of affordable housing, the construction of public infrastructure for emergency use and the transformation of villages in cities, and build a green, low-carbon, intelligent and safe house. It is necessary to rectify the order of the real estate market, rectify the chaos in real estate development, trading, intermediary and property, expose typical cases of violations of laws and regulations, and earnestly safeguard the legitimate rights and interests of the people.

  The Central Economic Work Conference proposed to actively and steadily resolve real estate risks, meet the reasonable financing needs of real estate enterprises with different ownership equally, and promote the stable and healthy development of the real estate market. Accelerate the construction of affordable housing, the construction of public infrastructure for both ordinary and emergency use, and the transformation of villages in cities. Improve the relevant basic systems and accelerate the construction of a new model of real estate development.

  The reporter noted that policy measures such as "meeting the reasonable financing needs of housing enterprises with different ownership equally" are being implemented. According to the latest data of the People’s Bank of China, by the end of 2023, five major banks, namely, industry, agriculture, China, construction and communications, had invested more than 30 billion yuan in development loans to non-state-owned housing enterprises.

  "Recently, loans from financial institutions to private housing enterprises are increasing, and financing to support private housing enterprises is accelerating. It is expected that the financing support policies for private housing enterprises will be further strengthened in the later period, and the financing of private housing enterprises in development loans, operating loans and bond underwriting will continue to increase. " Liu Shui, director of enterprise research at the China Central Finger Research Institute, told reporters.